Document Detail

Adhesion and invasion potential of rat prostatic cancer cells: correlation with metastatic potential.
MedLine Citation:
PMID:  8034439     Owner:  NLM     Status:  MEDLINE    
This investigation examined the ability of low-metastatic AT-1 and high-metastatic ML and MLL cell lines to adhere to a monolayer of bovine aortic endothelial cells and fibronectin substratum and penetrate a matrigel basement membrane matrix. Cell area, shape factor, and motility as influenced by fibronectin were also examined using these cell lines. The ability of these cells to adhere to fibronectin and traverse matrigel matrix correlated with their metastatic potential. In addition, fibronectin increases cell circularity and reduces cell area as metastatic potential increases within AT-1 to ML or MLL cell lineages.
C R Cooper; C Donald; N Emmett; S Harris-Hooker; D B Cooke
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Invasion & metastasis     Volume:  13     ISSN:  0251-1789     ISO Abbreviation:  Invasion Metastasis     Publication Date:  1993  
Date Detail:
Created Date:  1994-08-18     Completed Date:  1994-08-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8202435     Medline TA:  Invasion Metastasis     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  178-84     Citation Subset:  IM    
Department of Biological Sciences, Clark Atlanta University, Ga.
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MeSH Terms
Cell Adhesion
Fibronectins / physiology
Neoplasm Invasiveness
Neoplasm Metastasis*
Prostatic Neoplasms / pathology*
Tumor Cells, Cultured
Grant Support
S06 GM 45199-03/GM/NIGMS NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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