Document Detail

Adhesion of Human Breast Cancer Cells to Vascular Endothelium Mediated by Sialyl Lewis &supx; /E-selectin.
MedLine Citation:
PMID:  11091549     Owner:  NLM     Status:  Publisher    
The adhesion molecules involved in the attachment of breast cancer cells to endothelial cells were investigated in vitro. All six human breast cancer cell lines expressed sialyl Lewis &supx; antigen(s-Le &supx;). Only two cell lines expressed sialyl Lewis&supa; antigen. A correlation was found between the degree of s-Le&supx; expression and the attachment of cancer cells to human umbilical vein endothelial cells (HUVECs) activated by IL-1beta. Monoclonal antibodies against s-Le &supx; or E-selectin inhibited this adhesion. These findings suggest that s-Le &supx; on the surface of cancer cells and E-selectin on the surface of endothelial cells play roles in adheision of breast cancer cells to vascular endothelium.
Narita; Kawasaki-Kimura; Matsuura; Funahashi; Kannagi
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Publication Detail:
Journal Detail:
Title:  Breast cancer (Tokyo, Japan)     Volume:  3     ISSN:  1880-4233     ISO Abbreviation:  Breast Cancer     Publication Date:  1996 Mar 
Date Detail:
Created Date:  2000-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888201     Medline TA:  Breast Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  19-23     Citation Subset:  -    
Laboratory of Experimental Pathology, Research Institute, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya 464, Japan.
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