Document Detail


Adhesion of Human Breast Cancer Cells to Vascular Endothelium Mediated by Sialyl Lewis &supx; /E-selectin.
MedLine Citation:
PMID:  11091549     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The adhesion molecules involved in the attachment of breast cancer cells to endothelial cells were investigated in vitro. All six human breast cancer cell lines expressed sialyl Lewis &supx; antigen(s-Le &supx;). Only two cell lines expressed sialyl Lewis&supa; antigen. A correlation was found between the degree of s-Le&supx; expression and the attachment of cancer cells to human umbilical vein endothelial cells (HUVECs) activated by IL-1beta. Monoclonal antibodies against s-Le &supx; or E-selectin inhibited this adhesion. These findings suggest that s-Le &supx; on the surface of cancer cells and E-selectin on the surface of endothelial cells play roles in adheision of breast cancer cells to vascular endothelium.
Authors:
Narita; Kawasaki-Kimura; Matsuura; Funahashi; Kannagi
Related Documents :
20665479 - Optimization of ultrasound contrast agents with computational models to improve selecti...
15691739 - Co-expression of two mammalian glycosyltransferases in the yeast cell wall allows synth...
12234359 - Glycosylation in the control of selectin counter-receptor structure and function.
22210919 - Regulation of eosinophil trafficking by swap-70 and its role in allergic airway inflamm...
11891229 - Biosynthesis of hnk-1 glycans on o-linked oligosaccharides attached to the neural cell ...
22886489 - Effects of long-term water storage on the microtensile bond strength of five experiment...
8499079 - The roles of cd8 in cytotoxic t lymphocyte function.
15241559 - Tsh receptor signaling via cyclic amp inhibits cell surface degradation and internaliza...
9744839 - The role of inflammation after acute stroke: utility of pursuing anti-adhesion molecule...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Breast cancer (Tokyo, Japan)     Volume:  3     ISSN:  1880-4233     ISO Abbreviation:  Breast Cancer     Publication Date:  1996 Mar 
Date Detail:
Created Date:  2000-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888201     Medline TA:  Breast Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  19-23     Citation Subset:  -    
Affiliation:
Laboratory of Experimental Pathology, Research Institute, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya 464, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ca&sup2+;-Dependent Neutral Protease (Calpain) Activity in Breast Cancer Tissue and Estrogen Rec...
Next Document:  Suppression of Estrogenic Activity by Medroxyprogesterone Acetate in Tamoxifen-treated Patients afte...