Document Detail

Adhesion of Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum on bioactive TiO(2) surfaces.
MedLine Citation:
PMID:  22220677     Owner:  NLM     Status:  Publisher    
BACKGROUND: Bioactive TiO(2) coatings have been found to enhance fibroblast adhesion and gingival attachment on the titanium surfaces, but no information is available whether the coatings also promote the adhesion of periodontal pathogens. AIM: The purpose of this study was to investigate protein adsorption and the adhesion of Aggregatibacter actinomycetemcomitans (Aa) and Fusobacterium nucleatum (Fn) on bioactive TiO2 surfaces. MATERIALS AND METHODS: Commercially pure titanium discs (diameter 11.0 mm, grade 2) were coated with sol-gel derived bioactive TiO2 coatings (MetAlive, Vivoxid, Turku, Finland) and preincubated in 1.5 ml PBS/diluted serum/diluted saliva at room temperature to mimic the clinical situation after implantation and to allow serum/saliva proteins to adhere on the substrates. Uncoated titanium discs were used as controls. RESULTS: SDS-PAGE revealed similar protein profiles on bioactive and control titanium substrates. No differences were noticed in Aa or Fn adhesion between bioactive and control titanium. However, serum and saliva conditioning diminished Aa adhesion on both surfaces (p<0.001). CONCLUSION: It can be concluded that bioactive TiO2 coating does not promote adhesion of Aa and Fn.
Timo O Närhi; Heidi Leminen; Anna Haukioja; Eva Söderling
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-6
Journal Detail:
Title:  Clinical oral implants research     Volume:  -     ISSN:  1600-0501     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105713     Medline TA:  Clin Oral Implants Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Department of Prosthetic Dentistry, Institute of Dentistry, University of Turku, Turku, Finland; Clinic of Oral Diseases, Turku University Central Hospital, Turku, Finland; Turku Clinical Biomaterials Centre, Turku, Finland.
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