Document Detail


Adherent biofilms in adenotonsillar diseases in children.
MedLine Citation:
PMID:  18209130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study biofilm formation on the epithelial surfaces of tonsils and adenoids in children undergoing adenotonsillectomy (T&A). DESIGN: Prospective study. SETTING: Tertiary academic hospital. PATIENTS: Between September 2005 and August 2006, 76 patients (mean [SD] age, 5.7 [3.3] years; age range, 1-18 years; male-female ratio, 1.8:1) undergoing T&A to treat infection, obstruction, or both were included. Of these, 44 had obstruction (58%), 26 had infection (34%), and 6 had both (8%). INTERVENTIONS: Scanning electron microscopy was used to assess for the presence of biofilms. MAIN OUTCOME MEASURE: Presence of adherent biofilms on the surface epithelium of tonsils and adenoids. RESULTS: Adherent biofilm formation was demonstrated in 46 patients (61%). Among 26 patients with infections, adherent biofilm formation was detected in 22 (85%), whereas in the group of 44 patients with obstruction only 18 were found to have biofilms (41%). Comparative analysis of the data revealed that the difference was statistically significant (P = .01). CONCLUSIONS: Biofilms were identified on the surfaces of infected or enlarged tonsils and adenoids in most patients undergoing T&A. The presence of biofilms in a significantly higher proportion of patients with chronically inflamed tonsils and adenoids vs patients with obstruction indicates an association between the presence of biofilms and chronic inflammation.
Authors:
Khalid A Al-Mazrou; Abdulaziz S Al-Khattaf
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of otolaryngology--head & neck surgery     Volume:  134     ISSN:  0886-4470     ISO Abbreviation:  Arch. Otolaryngol. Head Neck Surg.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-22     Completed Date:  2008-03-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8603209     Medline TA:  Arch Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, King Abdul Aziz University Hospital, PO Box 86118, Riyadh 11622, Saudi Arabia. kalmazrou@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adenoidectomy
Adenoids / microbiology*,  surgery
Adolescent
Analysis of Variance
Biofilms*
Child
Child, Preschool
Female
Humans
Infant
Male
Microscopy, Electron, Scanning
Palatine Tonsil / microbiology*,  surgery
Prospective Studies
Tonsillectomy
Tonsillitis / microbiology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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