Document Detail


Adherence, persistence and continuation with cholinesterase inhibitors in Alzheimer's disease.
MedLine Citation:
PMID:  22950587     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  To determine adherence, persistence and continuation beyond 6 months with cholinesterase inhibitors in Australians with Alzheimer's disease. Methods:  Adherence and persistence with cholinesterase inhibitors were assessed by data linkage using the Pharmaceutical Benefits Scheme (PBS) Authority database and other health databases. Results:  Over 18 000 people commenced cholinesterase inhibitors during 2004. Adherence was 79.4% while the medication possession ratio was 0.88. Some 70.3% of people filled all six scripts for the initial trial period of therapy. Some 57.3% of evaluable patients accessed funding beyond six prescriptions, indicating that their clinicians had declared that there was a two-point or more greater improvement in the Mini-Mental State Examination. Despite the high rate of continuation beyond 6 months, the rates of institutionalisation and death were no different to those reported in clinical trials. Conclusions:  Persistence and adherence with cholinesterase inhibitors was reasonable once treatment was established. There was an unexpectedly high continuation rate beyond six prescriptions.
Authors:
David G Le Couteur; Maxine Robinson; Ann Leverton; Helen Creasey; Louise Waite; Kerry Atkins; Andrew J McLachlan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-4
Journal Detail:
Title:  Australasian journal on ageing     Volume:  31     ISSN:  1741-6612     ISO Abbreviation:  Australas J Ageing     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808874     Medline TA:  Australas J Ageing     Country:  -    
Other Details:
Languages:  ENG     Pagination:  164-169     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Australasian Journal on Ageing © 2011 ACOTA.
Affiliation:
Centre for Education and Research on Ageing, University of Sydney and Concord RG Hospital, Sydney, New South Wales; and Drug Utilisation Sub-committee, Pharmaceutical Evaluation Section, Pharmaceutical Benefits Branch, Department of Health and Ageing, Canberra, Australian Capital Territory, Australia Drug Utilisation Sub-committee, Pharmaceutical Evaluation Section, Pharmaceutical Benefits Branch, Department of Health and Ageing, Canberra, Australian Capital Territory, Australia Centre for Education and Research on Ageing, University of Sydney and Concord RG Hospital, Sydney, New South Wales, Australia Centre for Education and Research on Ageing, University of Sydney and Concord RG Hospital; and Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia.
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