| Adherence of peritonitis-causing staphylococci to human peritoneal mesothelial cell monolayers. | |
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MedLine Citation:
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PMID: 2299208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The adherence of staphylococci to monolayers of human mesothelial cells was studied. Adherence of Staphylococcus aureus to mesothelial cell monolayers was 3.4-fold better than to plastic (P less than .01) whereas that of Staphylococcus epidermidis was 3.0-fold less than to plastic (P less than .01). Neither serum albumin nor gelatin inhibited staphylococcal binding. S. aureus adherence correlated with the amount of cell wall protein A (r = .63, P less than .05) but not with fibronectin binding; it was significantly inhibited by the addition of purified cell wall lipoteichoic acid (55% +/- 2.7%), teichoic acid (34.5% +/- 3.4%), and protein A (25.6% +/- 2.9%) but not peptidoglycan. Protein A- and teichoic acid-deficient mutants adhered less well than their parent strains, and encapsulated S. epidermidis adhere well to human monothelial cells. Staphylococcal binding may involve cell wall lipoteichoic acid, teichoic acid, and protein A. |
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Authors:
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I A Haagen; H C Heezius; R P Verkooyen; J Verhoef; H A Verbrugh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 161 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-03-09 Completed Date: 1990-03-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 266-73 Citation Subset: AIM; IM |
Affiliation:
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Laboratory of Microbiology, University of Utrecht Medical School, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Adhesion* Blood Proteins / metabolism Cell Wall / metabolism Cells, Cultured Humans Lipopolysaccharides / metabolism Peptidoglycan / metabolism Peritoneum / microbiology* Peritonitis / microbiology* Staphylococcal Protein A / metabolism Staphylococcus aureus / metabolism*, ultrastructure Staphylococcus epidermidis / metabolism*, ultrastructure Teichoic Acids / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Lipopolysaccharides; 0/Peptidoglycan; 0/Staphylococcal Protein A; 0/Teichoic Acids; 56411-57-5/lipoteichoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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