| Adequate energy-protein intake is not enough to improve nutritional and metabolic status in muscle-depleted patients with chronic heart failure. | |
| | |
MedLine Citation:
|
PMID: 18835539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: An adequate energy-protein intake (EPI) when combined with amino acid supplementation may have a positive impact on nutritional and metabolic status in patients with chronic heart failure (CHF). METHODS AND RESULTS: Thirty eight stable CHF patients (27 males, 73.5+/-4 years; BMI 22.5+/-1.4 kg/m2), with severe depletion of muscle mass and were randomised to oral supplements of essential amino acids 8 g/day (EAA group; n=21) or no supplements (controls; n=17). All patients had adequate EPI (energy> or =30 kcal/kg; proteins >1.1 g/kg). At baseline and 2-months after randomisation, the patients underwent metabolic (plasma lactate, pyruvate concentration; serum insulin level; estimate of insulin resistance by HOMA index), nutritional (measure of nitrogen balance), and functional (exercise test, walking test) evaluations. Body weight increased by >1 kg in 80% of supplemented patients (mean 2.96 kg) and in 30% of controls (mean 2.3 kg) (interaction <0.05). Changes in arm muscle area, nitrogen balance, and HOMA index were similar between the two treatment groups. Plasma lactate and pyruvate levels increased in controls (p<0.01 for both) but decreased in the supplemented group (p<0.01 and 0.02 respectively). EAA supplemented patients but not controls improved both exercise output and peak oxygen consumption and walking test. CONCLUSIONS: Adequate EPI when combined with essential amino acid supplementation may improve nutritional and metabolic status in most muscle-depleted CHF patients. |
| | |
Authors:
|
Roberto Aquilani; Cristina Opasich; Alessandra Gualco; Manuela Verri; Amidio Testa; Evasio Pasini; Simona Viglio; Paolo Iadarola; Ornella Pastoris; Maurizia Dossena; Federica Boschi |
Related Documents
:
|
11896019 - Exercise training normalizes altered calcium-handling proteins during development of he... 16338939 - Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failur... 16377239 - Crt improves the exercise capacity and functional reserve of the failing heart through ... 11156889 - Allopurinol enhances the contractile response to dobutamine and exercise in dogs with p... 16079649 - Exercise training in chronic heart failure: correlation between reduced local inflammat... 3602219 - Selective enlargement of the third ventricle found in chronic schizophrenia. 12519649 - Olfactory function after mild traumatic brain injury. 1535589 - Effects of amiodarone on erect and supine exercise haemodynamics and exercise capacity ... 11841599 - A multifactorial approach employing melatonin to accelerate resynchronization of sleep-... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2008-10-04 |
Journal Detail:
|
Title: European journal of heart failure Volume: 10 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2008 Nov |
Date Detail:
|
Created Date: 2008-12-23 Completed Date: 2009-02-03 Revised Date: 2011-06-08 |
Medline Journal Info:
|
Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 1127-35 Citation Subset: IM |
Affiliation:
|
Servizio di Fisiopatologia Metabolico-Nutrizionale e Nutrizione Clinica, Fondazione S. Maugeri, IRCCS, Istituto Scientifico di Montescano, Montescano-Pavia, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Aged Aged, 80 and over Amino Acids, Essential / administration & dosage* Body Mass Index Body Weight / physiology Chronic Disease Dietary Proteins / administration & dosage* Energy Metabolism / physiology* Exercise Test Female Follow-Up Studies Heart Failure / diet therapy*, metabolism, physiopathology Humans Insulin / blood Lactates / blood Male Middle Aged Nutritional Status / physiology* Pyruvates / blood Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids, Essential; 0/Dietary Proteins; 0/Lactates; 0/Pyruvates; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Feline thyroid carcinoma: diagnosis and response to high-dose radioactive iodine treatment.
Next Document: Effect of matrix metalloproteinase-9 -1562C/T gene polymorphism on manifestations of pulmonary tuber...