Document Detail

Adequate dietary calcium mitigates osteopenia induced by chronic lead exposure in adult rats.
MedLine Citation:
PMID:  10436399     Owner:  NLM     Status:  MEDLINE    
The purpose of the present study was to investigate bone changes in the adult rat exposed to low lead levels during intake of normal dietary calcium and to contrast these findings with data from our earlier studies performed with animals receiving low dietary calcium concurrent with lead exposure. The present study exposed adult rats to 100 ppm lead via drinking water for 12 weeks and assessed bone histology, 1,25-dihydroxyvitamin D, 25(OH)vitamin D and parathyroid hormone levels. No osteopenia was evident by quantitative bone histology, and circulating levels of 1,25-dihydroxyvitamin D, 25(OH) vitamin D and parathyroid hormone were normal. Bone ash findings documented incorporation of significant amounts of lead into bone mineral. These findings document absence of interference with vitamin D metabolism, absence of secondary hyperparathyroidism and absence of osteopenia following 12 weeks of low lead exposure in the adult rat maintained on normal calcium intake. Results stress the importance of adequate calcium intake in our elderly population who may be exposed to cumulative, low-level lead exposure.
H E Gruber; Y Ding; A A Stasky; M Meyer; M R Pandian; D Pandian; N D Vaziri; J Grigsby; H C Gonick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mineral and electrolyte metabolism     Volume:  25     ISSN:  0378-0392     ISO Abbreviation:  Miner Electrolyte Metab     Publication Date:    1999 May-Jun
Date Detail:
Created Date:  1999-09-09     Completed Date:  1999-09-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7802196     Medline TA:  Miner Electrolyte Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  143-6     Citation Subset:  IM    
Department of Orthopaedic Surgery, Carolinas HealthCare System, Charlotte, NC 28232, USA.
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MeSH Terms
Bone Diseases, Metabolic / diet therapy*
Bone and Bones / metabolism
Calcium, Dietary / pharmacology*
Chronic Disease
Lead Poisoning / blood*
Minerals / metabolism
Rats, Sprague-Dawley
Reg. No./Substance:
0/Calcium, Dietary; 0/Minerals

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