Document Detail


Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress.
MedLine Citation:
PMID:  19106458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart failure remains the leading cause of mortality in the USA, despite major advances in therapy over the past several decades, including angiotensin-converting enzyme or angiotensin II inhibitors, vasodilators, calcium-channel blockers and beta-adrenergic receptor blockers. New therapeutic approaches are clearly required and the conceptual origin of these new techniques will be derived from agents that protect the heart against stress and prolong longevity. The combination of stress protection and longevity has been observed in a variety of organisms, from yeast to worms to mammals, and could be the basis for a novel approach to heart failure therapy. A mouse model has been developed with genetic disruption of adenylyl cyclase type 5, which lives one-third longer than the wild-type and is protected from aging-induced, pressure overload-induced and catecholamine-induced stresses. Accordingly, inhibition of this molecule should be considered as a new therapeutic modality for heart failure.
Authors:
Stephen F Vatner; Lin Yan; Yoshihiro Ishikawa; Dorothy E Vatner; Junichi Sadoshima
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2008-12-24
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-04-21     Revised Date:  2010-10-13    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  195-200     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School Newark, NJ 07103, USA. vatnersf@umdnj.edu
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MeSH Terms
Descriptor/Qualifier:
Adenylate Cyclase / genetics,  physiology*
Animals
Cardiomyopathies / physiopathology
Disease Models, Animal
Heart / physiology*
Heart Failure / physiopathology
Isoenzymes / genetics,  physiology*
Longevity / physiology*
Mice
Mice, Knockout
Oxidative Stress / physiology*
Grant Support
ID/Acronym/Agency:
AG014121/AG/NIA NIH HHS; AG023137/AG/NIA NIH HHS; AG027211/AG/NIA NIH HHS; HL033107/HL/NHLBI NIH HHS; HL059139/HL/NHLBI NIH HHS; HL069020/HL/NHLBI NIH HHS; HL069752/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 4.6.1.1/Adenylate Cyclase; EC 4.6.1.1/adenylyl cyclase type V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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