| Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress. | |
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MedLine Citation:
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PMID: 19106458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart failure remains the leading cause of mortality in the USA, despite major advances in therapy over the past several decades, including angiotensin-converting enzyme or angiotensin II inhibitors, vasodilators, calcium-channel blockers and beta-adrenergic receptor blockers. New therapeutic approaches are clearly required and the conceptual origin of these new techniques will be derived from agents that protect the heart against stress and prolong longevity. The combination of stress protection and longevity has been observed in a variety of organisms, from yeast to worms to mammals, and could be the basis for a novel approach to heart failure therapy. A mouse model has been developed with genetic disruption of adenylyl cyclase type 5, which lives one-third longer than the wild-type and is protected from aging-induced, pressure overload-induced and catecholamine-induced stresses. Accordingly, inhibition of this molecule should be considered as a new therapeutic modality for heart failure. |
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Authors:
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Stephen F Vatner; Lin Yan; Yoshihiro Ishikawa; Dorothy E Vatner; Junichi Sadoshima |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2008-12-24 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 73 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-23 Completed Date: 2009-04-21 Revised Date: 2010-10-13 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 195-200 Citation Subset: IM |
Affiliation:
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Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School Newark, NJ 07103, USA. vatnersf@umdnj.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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genetics,
physiology* Animals Cardiomyopathies / physiopathology Disease Models, Animal Heart / physiology* Heart Failure / physiopathology Isoenzymes / genetics, physiology* Longevity / physiology* Mice Mice, Knockout Oxidative Stress / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AG014121/AG/NIA NIH HHS; AG023137/AG/NIA NIH HHS; AG027211/AG/NIA NIH HHS; HL033107/HL/NHLBI NIH HHS; HL059139/HL/NHLBI NIH HHS; HL069020/HL/NHLBI NIH HHS; HL069752/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; EC 4.6.1.1/Adenylate Cyclase; EC 4.6.1.1/adenylyl cyclase type V |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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