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Adenylate kinase locus 1 polymorphism and feto-placental development.
MedLine Citation:
PMID:  21831515     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Recently our group has found that the correlation between birth weight and placental weight - an index of a balanced feto-placental unit development - is influenced by genetic factors. Since adenylate kinase locus 1 (AK(1)) is a polymorphic enzyme that plays an important role in the synthesis of nucleotides required for many metabolic functions, we have investigated the possible role of its genetic variability in the correlation between birth weight and placental weight. STUDY DESIGN: 342 consecutive healthy newborn infants from the population of Rome (Italy) and 286 puerperae from another population from Central Italy were studied. RESULTS: The correlation coefficient between birth weight and placental weight is much higher in infants with low activity AK(1)2-1 phenotype than in those with high activity AK(1)1 phenotype. The difference between AK(1) and AK(1)2-1 is well marked only in newborns with a gestational age greater than 38 weeks and it is not influenced by sex, maternal age and maternal smoking. A similar pattern is observed with maternal AK(1) phenotype. CONCLUSIONS: These results suggest that the difference in enzymatic activity between AK(1) phenotypes influencing the equilibrium among ATP, ADP, AMP and adenosine could have an important role in a balanced development of feto-placental unit.
Authors:
Gloria-Bottini Fulvia; Pietroiusti Antonio; Neri Anna; Saccucci Patrizia; Amante Ada; Bottini Egidio; Magrini Andrea
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-8
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  -     ISSN:  1872-7654     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Division of Biopathology of Human Population and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy.
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