Document Detail

Adenovirus infection induces reentry into the cell cycle of terminally differentiated skeletal muscle cells.
MedLine Citation:
PMID:  7755299     Owner:  NLM     Status:  MEDLINE    
Different cell types in the body of higher animals undergo terminal differentiation. In such a process, cells acquire specialized functions and irreversibly lose their ability to divide, therefore entering the postmitotic state. Terminally differentiated cells do not proliferate in response to growth factors or following the expression of activated, retroviral oncogenes. In this paper we demonstrate that adenovirus infection is an efficient and convenient means to induce terminally differentiated cells to reenter the cell cycle. These findings constitute a first step toward defining the molecular determinants of the irreversible withdrawal from the cell cycle of terminally differentiated cells. They may also open the way to therapeutic applications.
M Crescenzi; S Soddu; A Sacchi; F Tatò
Related Documents :
21349849 - Mutant hfe h63d protein is associated with prolonged endoplasmic reticulum stress and i...
19453639 - Basic fibroblast growth factor increases the precursor pool of photoreceptors, but inhi...
21459079 - Neurotoxicity of methotrexate to hippocampal cells in vivo and in vitro.
9917519 - The involvement of proteasome in myogenic differentiation of murine myocytes and human ...
11950599 - Differentiated hl-60 cells are a valid model system for the analysis of human neutrophi...
16107889 - Translational study of vitamin d differentiation therapy of myeloid leukemia: effects o...
14637149 - Negative regulation of p21 by beta-catenin/tcf signaling: a novel mechanism by which ce...
21337009 - Germ cell sex prior to meiosis in the rainbow trout.
1542439 - Epidermal growth factor-induced survival and proliferation of neuronal precursor cells ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  752     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-06-16     Completed Date:  1995-06-16     Revised Date:  2012-02-27    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-18     Citation Subset:  IM    
Department of Cellular and Developmental Biology, University of Rome, La Sapienza, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenoviruses, Human* / genetics
Antibodies, Monoclonal
Cell Cycle / physiology*
Cell Differentiation
Cell Line
Cell Line, Transformed
DNA / biosynthesis
Muscle, Skeletal / cytology*,  metabolism
Myosins / biosynthesis
Sequence Deletion
Grant Support
Reg. No./Substance:
0/Antibodies, Monoclonal; 9007-49-2/DNA; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cardiac myocyte terminal differentiation. Potential for cardiac regeneration.
Next Document:  In vitro clonal analysis of cardiac outflow tract mesenchyme.