Document Detail


Adenovirus infection induces reentry into the cell cycle of terminally differentiated skeletal muscle cells.
MedLine Citation:
PMID:  7755299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Different cell types in the body of higher animals undergo terminal differentiation. In such a process, cells acquire specialized functions and irreversibly lose their ability to divide, therefore entering the postmitotic state. Terminally differentiated cells do not proliferate in response to growth factors or following the expression of activated, retroviral oncogenes. In this paper we demonstrate that adenovirus infection is an efficient and convenient means to induce terminally differentiated cells to reenter the cell cycle. These findings constitute a first step toward defining the molecular determinants of the irreversible withdrawal from the cell cycle of terminally differentiated cells. They may also open the way to therapeutic applications.
Authors:
M Crescenzi; S Soddu; A Sacchi; F Tatò
Related Documents :
2473769 - Activation of murine b cells with salmonella typhimurium mitogen (stm), lipopolysacchar...
8780009 - Increased expression of ubiquitin during adenosine 3',5'-cyclic monophosphate-induced d...
19453639 - Basic fibroblast growth factor increases the precursor pool of photoreceptors, but inhi...
20209049 - Differentiation of symbiotic cells and endosymbionts in medicago truncatula nodulation ...
9176839 - Induction of differentiation in cultured rat and human podocytes.
1528069 - Effects of lithium on dimethyl sulfoxide induced differentiation of hl-60 promyelocytic...
21559449 - Generation of a predictive melphalan resistance index by drug screen of b-cell cancer c...
9458389 - Efficiency of single-cell polymerase chain reaction from stained histologic slides and ...
7528889 - Phases of the cell cycle sensitive to endoreduplication induction in cho-k1 cells.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  752     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-06-16     Completed Date:  1995-06-16     Revised Date:  2012-02-27    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-18     Citation Subset:  IM    
Affiliation:
Department of Cellular and Developmental Biology, University of Rome, La Sapienza, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenoviruses, Human* / genetics
Animals
Antibodies, Monoclonal
Cell Cycle / physiology*
Cell Differentiation
Cell Line
Cell Line, Transformed
DNA / biosynthesis
Humans
Kinetics
Mitosis
Muscle, Skeletal / cytology*,  metabolism
Myosins / biosynthesis
Sequence Deletion
Grant Support
ID/Acronym/Agency:
467//Telethon
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 9007-49-2/DNA; EC 3.6.4.1/Myosins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cardiac myocyte terminal differentiation. Potential for cardiac regeneration.
Next Document:  In vitro clonal analysis of cardiac outflow tract mesenchyme.