Document Detail

Adenovirus infection induces reentry into the cell cycle of terminally differentiated skeletal muscle cells.
MedLine Citation:
PMID:  7755299     Owner:  NLM     Status:  MEDLINE    
Different cell types in the body of higher animals undergo terminal differentiation. In such a process, cells acquire specialized functions and irreversibly lose their ability to divide, therefore entering the postmitotic state. Terminally differentiated cells do not proliferate in response to growth factors or following the expression of activated, retroviral oncogenes. In this paper we demonstrate that adenovirus infection is an efficient and convenient means to induce terminally differentiated cells to reenter the cell cycle. These findings constitute a first step toward defining the molecular determinants of the irreversible withdrawal from the cell cycle of terminally differentiated cells. They may also open the way to therapeutic applications.
M Crescenzi; S Soddu; A Sacchi; F Tatò
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  752     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-06-16     Completed Date:  1995-06-16     Revised Date:  2012-02-27    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-18     Citation Subset:  IM    
Department of Cellular and Developmental Biology, University of Rome, La Sapienza, Italy.
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MeSH Terms
Adenoviruses, Human* / genetics
Antibodies, Monoclonal
Cell Cycle / physiology*
Cell Differentiation
Cell Line
Cell Line, Transformed
DNA / biosynthesis
Muscle, Skeletal / cytology*,  metabolism
Myosins / biosynthesis
Sequence Deletion
Grant Support
Reg. No./Substance:
0/Antibodies, Monoclonal; 9007-49-2/DNA; EC

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