Document Detail


Adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines.
MedLine Citation:
PMID:  12375026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We reconstructed the recombinant p53-expressing adenovirus and examined its infections and effects in head and neck squamous cell carcinoma cell lines. Eight human head and neck squamous cell carcinoma cell lines were infected by the recombinant adenovirus harboring the lacZ gene (AxCAiLacZ) or the wild-type p53 gene (AxCAip53), and the effects were investigated. The eight cell lines were successfully infected by AxCAiLacZ at a level of more than 50%. The survival of all 8 squamous cell lines were inhibited in the range from 8 to 26.7% by only one treatment of the AxCAip53 infection. This result suggested that p53 gene therapy might become a useful tool in head and neck squamous cell carcinoma treatment.
Authors:
Yuzuru Higuchi; Jun-Ichi Asaumi; Jun Murakami; Toru Wakasa; Tetsuyoshi Inoue; Masahiro Kuroda; Koichi Shibuya; Hiroshi Shigehara; Shoji Kawasaki; Kazuhiro Fukui; Kanji Kishi; Yoshio Hiraki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncology reports     Volume:  9     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:    2002 Nov-Dec
Date Detail:
Created Date:  2002-10-10     Completed Date:  2003-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1233-6     Citation Subset:  IM    
Affiliation:
Department of Oral and Maxillofacial Radiology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenoviridae / genetics*
Carcinoma, Squamous Cell / metabolism,  pathology,  therapy*
Cell Survival
DNA Primers / chemistry
Galactosides / metabolism
Gene Therapy*
Genes, p53*
Head and Neck Neoplasms / metabolism,  pathology,  therapy*
Humans
Indoles / metabolism
Lac Operon
Polymerase Chain Reaction
Transfection
Tumor Cells, Cultured
beta-Galactosidase / metabolism
Chemical
Reg. No./Substance:
0/DNA Primers; 0/Galactosides; 0/Indoles; 7240-90-6/5-bromo-4-chloro-3-indolyl beta-galactoside; EC 3.2.1.23/beta-Galactosidase

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