Document Detail

Adenosquamous carcinoma of the upper aerodigestive tract: a clinicopathologic study of 12 cases and review of the literature.
MedLine Citation:
PMID:  12019485     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Adenosquamous carcinoma is an uncommon, controversial neoplasm. To further comprehend its natural history, the clinical and pathological features of 12 new cases were reviewed and analyzed collectively with those described in the English literature. MATERIALS AND METHODS: Twelve cases of adenosquamous carcinoma of the upper aerodigestive tract with adequate follow-up and available microscopic slides and paraffin tissue blocks were identified in the anatomic pathology files of Presbyterian Hospital of the University of Pittsburgh Medical Center over the period 1983-2001. RESULTS: The 8 men and 4 women ranged in age from 34 to 81 years (mean, 62.8 years). The larynx (5 cases) and the floor of the mouth (4 cases) were the most common sites of origin. Nine patients had cervical lymph nodes positive for carcinoma (8 at diagnosis), 7 experienced local recurrences, and 2 developed distant metastases. Four of 10 (40%) patients with follow-up died of disease. Combining our cases with those in the literature (total of 58 cases) revealed similar findings: 64.7% were associated with positive cervical lymph nodes, 46.7% experienced local recurrences, 23.1% developed distant metastases, and 42.9% died of their disease at a mean follow-up period of 24.7 months. CONCLUSIONS: Adenosquamous carcinoma is an aggressive neoplasm with a tendency for early lymph node metastasis, frequent local recurrence, occasional distant metastasis, and death from disease, usually within 2-3 years. Surgery with neck dissection is the treatment of choice.
Somboon Keelawat; Cheng Zheng Liu; Pamela C Roehm; Leon Barnes
Related Documents :
8311185 - Atypical mitotic figures in basal cell carcinoma. a review of 208 cases.
8738065 - Malakoplakia of the prostate gland--report of two cases and review of the literature.
10343945 - Squamous cell carcinoma of the penis arising on lichen sclerosus et atrophicus.
6307705 - Studies on nasopharyngeal carcinoma in the sudan--i. epidemiology and aetiology.
1602265 - Case report with review of aeromonas infection.
2762185 - Management of an early ankylosed mandibular second primary molar: case report.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of otolaryngology     Volume:  23     ISSN:  0196-0709     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-05-20     Completed Date:  2002-06-21     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-8     Citation Subset:  IM    
Copyright Information:
Copyright 2002, Elsevier Science (USA). All rights reserved.)
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Carcinoma, Adenosquamous / pathology*,  therapy
Digestive System Neoplasms / pathology*,  therapy
Middle Aged
Outcome Assessment (Health Care)
Respiratory Tract Neoplasms / pathology*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Color duplex sonography in post-therapeutic neck evaluation.
Next Document:  Myasthenia gravis: the otolaryngologist's perspective.