Document Detail

Adenosquamous carcinoma of the upper aerodigestive tract: a clinicopathologic study of 12 cases and review of the literature.
MedLine Citation:
PMID:  12019485     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Adenosquamous carcinoma is an uncommon, controversial neoplasm. To further comprehend its natural history, the clinical and pathological features of 12 new cases were reviewed and analyzed collectively with those described in the English literature. MATERIALS AND METHODS: Twelve cases of adenosquamous carcinoma of the upper aerodigestive tract with adequate follow-up and available microscopic slides and paraffin tissue blocks were identified in the anatomic pathology files of Presbyterian Hospital of the University of Pittsburgh Medical Center over the period 1983-2001. RESULTS: The 8 men and 4 women ranged in age from 34 to 81 years (mean, 62.8 years). The larynx (5 cases) and the floor of the mouth (4 cases) were the most common sites of origin. Nine patients had cervical lymph nodes positive for carcinoma (8 at diagnosis), 7 experienced local recurrences, and 2 developed distant metastases. Four of 10 (40%) patients with follow-up died of disease. Combining our cases with those in the literature (total of 58 cases) revealed similar findings: 64.7% were associated with positive cervical lymph nodes, 46.7% experienced local recurrences, 23.1% developed distant metastases, and 42.9% died of their disease at a mean follow-up period of 24.7 months. CONCLUSIONS: Adenosquamous carcinoma is an aggressive neoplasm with a tendency for early lymph node metastasis, frequent local recurrence, occasional distant metastasis, and death from disease, usually within 2-3 years. Surgery with neck dissection is the treatment of choice.
Somboon Keelawat; Cheng Zheng Liu; Pamela C Roehm; Leon Barnes
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of otolaryngology     Volume:  23     ISSN:  0196-0709     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-05-20     Completed Date:  2002-06-21     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-8     Citation Subset:  IM    
Copyright Information:
Copyright 2002, Elsevier Science (USA). All rights reserved.)
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
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MeSH Terms
Aged, 80 and over
Carcinoma, Adenosquamous / pathology*,  therapy
Digestive System Neoplasms / pathology*,  therapy
Middle Aged
Outcome Assessment (Health Care)
Respiratory Tract Neoplasms / pathology*,  therapy

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