Document Detail

Adenosquamous carcinoma of the head and neck: relationship to human papillomavirus and review of the literature.
MedLine Citation:
PMID:  21305368     Owner:  NLM     Status:  MEDLINE    
Adenosquamous carcinoma (ADSC) of the head and neck is an aggressive variant of squamous cell carcinoma (SCC). Certain variants of head and neck SCC are human papillomavirus (HPV)-related and have better prognosis. The relationship of HPV to head and neck ADSC has not been investigated. We searched our files for the term "adenosquamous" and head and neck subsites and found cases from 1998 to 2009. The requisite histologic criteria were the presence of SCC combined with distinct gland formation and/or intracellular mucin. DNA in situ hybridization for high-risk HPV, RNA in situ hybridization for high risk HPV E6 and E7 transcripts, and immunohistochemistry for p16 and p53 were performed. The existing literature on ADSC was also reviewed. Of the 18 cases, eight were from the larynx and hypopharynx, four from the oral cavity, three from the oropharynx, and three from the nasal cavity. Three cases (16%) showed both high risk HPV E6 and E7 and p16 expression, one from the nasal cavity and two from the oropharynx. Both oropharyngeal carcinoma patients were alive and disease free at 34 and 103 months, respectively. ADSCs of the head and neck are a heterogeneous group of tumors. A small minority of cases harbor HPV and most of these, particularly those occurring at sites with known high prevalence of HPV, show active viral transcription with detectable E6 and E7 and overexpression of p16. The HPV-related oropharyngeal cases, though rare, appear to do very well clinically, while the remaining cohort of ADSC patients do quite poorly. Head and neck ADSC appears to be a mixed variant that can be further classified according to its HPV status.
Ramya P Masand; Samir K El-Mofty; Xiao-Jun Ma; Yuling Luo; John J Flanagan; James S Lewis
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2011-02-09
Journal Detail:
Title:  Head and neck pathology     Volume:  5     ISSN:  1936-0568     ISO Abbreviation:  Head Neck Pathol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-20     Completed Date:  2011-09-08     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101304010     Medline TA:  Head Neck Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  108-16     Citation Subset:  IM    
Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
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MeSH Terms
Aged, 80 and over
Alphapapillomavirus / isolation & purification*,  physiology
Carcinoma, Adenosquamous / metabolism,  secondary*,  virology
Carcinoma, Squamous Cell / metabolism,  secondary*,  virology
DNA, Viral / analysis
Fatal Outcome
Head and Neck Neoplasms / metabolism,  pathology*,  virology
In Situ Hybridization
Middle Aged
Neoplasm Proteins / metabolism
Neoplasm Staging
Neoplasms, Multiple Primary
Oncogene Proteins, Viral / metabolism
Papillomavirus E7 Proteins / metabolism
Papillomavirus Infections / complications,  metabolism,  pathology*
RNA, Viral / analysis
Repressor Proteins / metabolism
Tumor Markers, Biological / metabolism
Tumor Suppressor Protein p53 / metabolism
Young Adult
Reg. No./Substance:
0/DNA, Viral; 0/E6 protein, Human papillomavirus type 16; 0/Neoplasm Proteins; 0/Oncogene Proteins, Viral; 0/P16 protein, human; 0/Papillomavirus E7 Proteins; 0/RNA, Viral; 0/Repressor Proteins; 0/Tumor Markers, Biological; 0/Tumor Suppressor Protein p53; 0/oncogene protein E7, Human papillomavirus type 16

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