Document Detail


Adenosis of the prostate. Histologic features in transurethral resection specimens.
MedLine Citation:
PMID:  7520673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adenosis (atypical adenomatous hyperplasia, small gland hyperplasia) of the prostate is characterized by a relatively well-circumscribed proliferation of benign glands that frequently mimics low-grade adenocarcinoma. Although general reviews of adenosis exist, relatively few specialized studies have characterized the histologic features of adenosis. The purpose of this study was to review and better document the histologic features of adenosis. Forty-four transurethral resection (TUR) specimens containing a total of 145 foci of adenosis were evaluated for the presence or absence of six histologic features: mitotic figures, blue-tinged luminal mucinous secretions, intraluminal crystalloids, single cells, a focally infiltrative growth pattern, and prominent nucleoli. Immunohistochemical stains for high-molecular-weight cytokeratin were performed on 66 (46%) of the foci to confirm the presence of a basal cell layer and thus the diagnosis of adenosis. Crystalloids were present in 58 foci (40%), an infiltrative growth pattern in 27 foci (19%), single cells in 23 foci (16%), prominent nucleoli in 22 foci (15%), mitotic figures in 16 foci (11%), and blue-tinged luminal mucinous secretions in 3 foci (2%). The diagnosis of adenosis is based on a constellation of histologic features and may be confirmed with the use of antibodies to high-molecular-weight cytokeratin.
Authors:
P B Gaudin; J I Epstein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  18     ISSN:  0147-5185     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-19     Completed Date:  1994-09-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  863-70     Citation Subset:  IM    
Affiliation:
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21287.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / pathology*
Aged
Aged, 80 and over
Diagnosis, Differential
Humans
Male
Middle Aged
Prostatectomy
Prostatic Hyperplasia / pathology*
Prostatic Neoplasms / pathology*
Comments/Corrections
Comment In:
Am J Surg Pathol. 1995 Aug;19(8):973   [PMID:  7611548 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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