Document Detail

Adenosine and verapamil-sensitive ventricular tachycardia originating from the left ventricle: radiofrequency catheter ablation.
MedLine Citation:
PMID:  1282244     Owner:  NLM     Status:  MEDLINE    
A ventricular tachycardia (VT) with right bundle branch block (RBBB) QRS morphology and left axis originating from the inferoapical segment of the left ventricle is described in a 49-year-old man without structural heart disease. This VT could be initiated during isoproterenol infusion and was terminated with intravenous administration of adenosine and verapamil. Radiofrequency ablation eliminated the tachycardia. Previous reports have suggested reentry as the mechanism for a verapamil-sensitive VT with this ECG morphology, while cAMP-mediated triggered activity has been proposed as a mechanism for VTs sensitive to adenosine. The latter more typically arise in the right ventricular outflow tract. The electrophysiological and electropharmacological characteristics of the tachycardia in this patient suggest that this VT morphology is not specific for a mechanism but rather for the location of the site of origin.
W A DeLacey; S Nath; D E Haines; M J Barber; J P DiMarco
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  15     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-02     Completed Date:  1993-02-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2240-4     Citation Subset:  IM    
Division of Cardiology, University of Virginia Health Sciences Center, Charlottesville 22908.
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MeSH Terms
Adenosine / pharmacology*
Bundle-Branch Block / physiopathology
Cardiac Pacing, Artificial
Catheter Ablation*
Heart Conduction System / drug effects
Isoproterenol / diagnostic use
Middle Aged
Tachycardia, Ventricular / diagnosis,  physiopathology,  surgery*
Ventricular Function, Left / physiology
Verapamil / pharmacology*
Reg. No./Substance:
52-53-9/Verapamil; 58-61-7/Adenosine; 7683-59-2/Isoproterenol
Comment In:
Pacing Clin Electrophysiol. 1993 Sep;16(9):1906-7   [PMID:  7692426 ]

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