Document Detail


Adenosine triphosphate liposomes: encapsulation and distribution studies.
MedLine Citation:
PMID:  2367324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four methods for encapsulating adenosine triphosphate (ATP) in liposomes were evaluated. Optimum entrapment required emulsifying ATP with the lipids used to form the liposome membrane in a high-speed homogenizer followed by evaporating the organic solvent with vigorous stirring. Under these optimum conditions ATP entrapment was 38.9%; i.e., the dosage form contained 38.9 g of ATP per 100 g of lipid. The distribution of positively charged liposomes loaded with ATP was studied in dogs with experimentally induced myocardial infarction. Intravenous injection of positively charged ATP liposomes caused accumulation of ATP in myocardial infarct tissue. Myocardial infarct tissue has reduced blood flow; since positively charged liposomes accumulated in infarct tissue, liposomes may be a drug delivery system for this disease state.
Authors:
G X Xu; X H Xie; F Y Liu; D L Zang; D S Zheng; D J Huang; M X Huang
Related Documents :
7011784 - Terminals of reserpine-sensitive vasopressin-neurophysin neurons in the external layer ...
17653104 - Urokinase gene transfer augments angiogenesis in ischemic skeletal and myocardial muscle.
10994734 - The role of fatty acids in cardiac imaging.
12060524 - Effects of recombinant staphylokinase on coronary thrombosis in chinese experimental mi...
22548574 - The future: therapy of myocardial protection.
19936114 - Heart rate and cardiovascular disease: an alternative to beta blockers.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmaceutical research     Volume:  7     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-16     Completed Date:  1990-08-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  553-7     Citation Subset:  IM    
Affiliation:
Shanghai Institute of Pharmaceutical Industry, State Pharmaceutical Administration of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / administration & dosage*,  pharmacokinetics
Animals
Capsules
Dogs
Drug Compounding
Liposomes
Myocardial Infarction / metabolism
Chemical
Reg. No./Substance:
0/Capsules; 0/Liposomes; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effect of sodium tauro-24,25-dihydrofusidate on the nasal absorption of human growth hormone in ...
Next Document:  Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of benzodiazepines. II. ...