Document Detail

Adenosine triphosphate liposomes: encapsulation and distribution studies.
MedLine Citation:
PMID:  2367324     Owner:  NLM     Status:  MEDLINE    
Four methods for encapsulating adenosine triphosphate (ATP) in liposomes were evaluated. Optimum entrapment required emulsifying ATP with the lipids used to form the liposome membrane in a high-speed homogenizer followed by evaporating the organic solvent with vigorous stirring. Under these optimum conditions ATP entrapment was 38.9%; i.e., the dosage form contained 38.9 g of ATP per 100 g of lipid. The distribution of positively charged liposomes loaded with ATP was studied in dogs with experimentally induced myocardial infarction. Intravenous injection of positively charged ATP liposomes caused accumulation of ATP in myocardial infarct tissue. Myocardial infarct tissue has reduced blood flow; since positively charged liposomes accumulated in infarct tissue, liposomes may be a drug delivery system for this disease state.
G X Xu; X H Xie; F Y Liu; D L Zang; D S Zheng; D J Huang; M X Huang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmaceutical research     Volume:  7     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-16     Completed Date:  1990-08-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  553-7     Citation Subset:  IM    
Shanghai Institute of Pharmaceutical Industry, State Pharmaceutical Administration of China.
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MeSH Terms
Adenosine Triphosphate / administration & dosage*,  pharmacokinetics
Drug Compounding
Myocardial Infarction / metabolism
Reg. No./Substance:
0/Capsules; 0/Liposomes; 56-65-5/Adenosine Triphosphate

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