Document Detail

Adenosine triphosphate attenuates renal sympathetic nerve activity through left ventricular chemosensitive receptors.
MedLine Citation:
PMID:  9023265     Owner:  NLM     Status:  MEDLINE    
We previously reported that ATP, but not adenosine, administered i.v. attenuates the baroreflex-mediated increase in sympathetic nerve activity in response to arterial hypotension by a vagal afferent mechanism. It was not elucidated in that study which vagal afferent endings are involved. Mongrel dogs were anesthetized with alpha-chloralose, thoracotomy was performed and a 27-gauge hypodermic needle was inserted into the left circumflex coronary artery. The left renal sympathetic nerves were isolated and placed on a bipolar silver electrode for measurement of renal sympathetic nerve activity (RSNA). Dose-response effects of intracoronary or i.v. infusion of ATP (100, 200 or 400 microg/kg/min) on RSNA and mean arterial pressure were studied in neuraxis-intact and cervically vagotomized dogs. RSNA was increased dose-dependently with decreasing mean arterial pressure during the i.v. ATP infusion. Elevation of RSNA was attenuated by higher intracoronary ATP infusion rates, despite the fact that mean arterial pressure was decreased dose-dependently. Left ventricular end-diastolic pressure, however, remained unchanged. This suppression of RSNA by the intracoronary ATP infusion was completely abolished by bilateral cervical vagotomy. Our data suggest that ATP attenuates reflex increases in sympathetic nerve activity by possibly stimulating ventricular chemoreceptors with cardiac vagal afferents.
C Taneyama; K T Benson; P G Hild; H Goto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  280     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-03-17     Completed Date:  1997-03-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  570-5     Citation Subset:  IM    
Department of Anesthesiology, University of Kansas Medical Center, Kansas City 66160-7415, USA.
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MeSH Terms
Adenosine Triphosphate / administration & dosage,  pharmacology*
Blood Pressure / drug effects
Chemoreceptor Cells / drug effects,  physiology*
Coronary Vessels / drug effects,  physiology*
Dose-Response Relationship, Drug
Heart Rate / drug effects
Infusions, Intra-Arterial
Infusions, Intravenous
Kidney / innervation*
Sympathetic Nervous System / drug effects,  physiology*
Ventricular Function, Left / drug effects
Reg. No./Substance:
56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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