| Adenosine triphosphate attenuates renal sympathetic nerve activity through left ventricular chemosensitive receptors. | |
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MedLine Citation:
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PMID: 9023265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously reported that ATP, but not adenosine, administered i.v. attenuates the baroreflex-mediated increase in sympathetic nerve activity in response to arterial hypotension by a vagal afferent mechanism. It was not elucidated in that study which vagal afferent endings are involved. Mongrel dogs were anesthetized with alpha-chloralose, thoracotomy was performed and a 27-gauge hypodermic needle was inserted into the left circumflex coronary artery. The left renal sympathetic nerves were isolated and placed on a bipolar silver electrode for measurement of renal sympathetic nerve activity (RSNA). Dose-response effects of intracoronary or i.v. infusion of ATP (100, 200 or 400 microg/kg/min) on RSNA and mean arterial pressure were studied in neuraxis-intact and cervically vagotomized dogs. RSNA was increased dose-dependently with decreasing mean arterial pressure during the i.v. ATP infusion. Elevation of RSNA was attenuated by higher intracoronary ATP infusion rates, despite the fact that mean arterial pressure was decreased dose-dependently. Left ventricular end-diastolic pressure, however, remained unchanged. This suppression of RSNA by the intracoronary ATP infusion was completely abolished by bilateral cervical vagotomy. Our data suggest that ATP attenuates reflex increases in sympathetic nerve activity by possibly stimulating ventricular chemoreceptors with cardiac vagal afferents. |
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Authors:
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C Taneyama; K T Benson; P G Hild; H Goto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 280 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-03-17 Completed Date: 1997-03-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 570-5 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, University of Kansas Medical Center, Kansas City 66160-7415, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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administration & dosage,
pharmacology* Animals Baroreflex* Blood Pressure / drug effects Chemoreceptor Cells / drug effects, physiology* Coronary Vessels / drug effects, physiology* Dogs Dose-Response Relationship, Drug Heart Rate / drug effects Infusions, Intra-Arterial Infusions, Intravenous Kidney / innervation* Sympathetic Nervous System / drug effects, physiology* Vagotomy Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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