Document Detail

Adenosine stress cardiac magnetic resonance imaging for the assessment of ischemic heart disease.
MedLine Citation:
PMID:  18777000     Owner:  NLM     Status:  MEDLINE    
AIMS: This prospective study was designed to determine the diagnostic value of adenosine stress cardiac magnetic resonance imaging (CMRI) in patients referred to elective coronary angiography. METHODS AND RESULTS: Myocardial perfusion measurements at rest and adenosine stress were performed in 141 patients (105 men, 36 women, mean age 63.4 years) at 1.5 T with a Turbo Flash sequence. Stress-induced perfusion deficits were correlated to angiographic stenoses > or =75%. The overall sensitivity for CMRI depicting coronary artery disease (CAD) with relevant stenoses was 90.4%, the specificity was 77.4%, the positive predictive value was 85.9%, the negative predictive value was 84.2% and the accuracy 85.2%. Subgroup analysis was performed for 3-vessel disease (n = 44, sensitivity 92.3%, specificity 75.0%), 2-vessel disease (n = 43, sensitivity 92.6%, specificity 92.9%), 1-vessel disease (n = 27, sensitivity 93.1%, specificity 71.4%) and patients without CAD (n = 27, specificity 70.4%) as well as for patients with prior myocardial infarction (n = 44, sensitivity 92.9%, specificity 86.7%), prior coronary artery bypass surgery (n = 21, sensitivity 88.2%, specificity 66.7%), prior coronary interventions (n = 88, sensitivity 91.9%, specificity 75.0%), or diabetics (n = 27, sensitivity 90.5%, specificity 83.3%). CONCLUSION: Our study shows that stress perfusion CMRI can accurately predict relevant CAD and contributes to the identification of hemodynamic relevant stenoses in patients scheduled for coronary angiography.
Christina Doesch; Achim Seeger; Tobias Hoevelborn; Bernhard Klumpp; Michael Fenchel; Ulrich Kramer; Birgitt Schönfisch; Claus D Claussen; Meinrad Gawaz; Stephan Miller; Andreas E May
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2008-09-05
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  97     ISSN:  1861-0692     ISO Abbreviation:  -     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  905-12     Citation Subset:  IM    
Department of Cardiology, Eberhard Karls University, Tübingen, Otfried-Müller Str. 10, 72076, Tübingen, Germany.
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MeSH Terms
Adenosine / diagnostic use*
Coronary Artery Disease / diagnosis
Coronary Stenosis / diagnosis
Diabetes Mellitus / physiopathology
Magnetic Resonance Angiography / methods*
Middle Aged
Myocardial Ischemia / diagnosis*
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Vasodilator Agents / diagnostic use*
Reg. No./Substance:
0/Vasodilator Agents; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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