Document Detail


Adenosine signaling during acute and chronic disease states.
MedLine Citation:
PMID:  23340998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adenosine is a signaling nucleoside that is produced following tissue injury, particularly injury involving ischemia and hypoxia. The production of extracellular adenosine and its subsequent signaling through adenosine receptors plays an important role in orchestrating injury responses in multiple organs. There are four adenosine receptors that are widely distributed on immune, epithelial, endothelial, neuronal,and stromal cells throughout the body. Interestingly, these receptors are subject to altered regulation following injury. Studies in mouse models and human cells and tissues have identified that the production of adenosine and its subsequent signaling through its receptors plays largely beneficial roles in acute disease states, with the exception of brain injury. In contrast, if elevated adenosine levels are sustained beyond the acute injury phase, adenosine responses can become detrimental by activating pathways that promote tissue injury and fibrosis. Understanding when during the course of disease adenosine signaling is beneficial as opposed to detrimental and defining the mechanisms involved will be critical for the advancement of adenosine-based therapies for acute and chronic diseases. The purpose of this review is to discuss key observations that define the beneficial and detrimental aspects of adenosine signaling during acute and chronic disease states with an emphasis on cellular processes, such as inflammatory cell regulation, vascular barrier function, and tissue fibrosis.
Authors:
Harry Karmouty-Quintana; Yang Xia; Michael R Blackburn
Related Documents :
24239118 - Activation of gabaergic neurons in the interpeduncular nucleus triggers physical nicoti...
23913978 - Molecular determinants for ligand binding at serotonin 5-ht2a and 5-ht2c gpcrs: experim...
1688218 - Non-nmda type excitatory amino acid receptors mediate rod input to horizontal cells in ...
23137448 - Fibrate-derived n-(methylsulfonyl)amides with antagonistic properties on pparα
20410458 - Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor sp...
12438928 - Neuroprotective activity of chf3381, a putative n-methyl-d-aspartate receptor antagonist.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-23
Journal Detail:
Title:  Journal of molecular medicine (Berlin, Germany)     Volume:  91     ISSN:  1432-1440     ISO Abbreviation:  J. Mol. Med.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-30     Completed Date:  2013-07-30     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9504370     Medline TA:  J Mol Med (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  173-81     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adenosine / metabolism*
Animals
Chronic Disease
Humans
Signal Transduction
Grant Support
ID/Acronym/Agency:
DK083559/DK/NIDDK NIH HHS; HL070952/HL/NHLBI NIH HHS; R01 HL070952/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
K72T3FS567/Adenosine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Microwave-assisted technology for the clearing and staining of arbuscular mycorrhizal fungi in roots...
Next Document:  Microchip-based electrochemical detection for monitoring cellular systems.