Document Detail

Adenosine is a sensitive oxygen sensor in the heart.
MedLine Citation:
PMID:  2253717     Owner:  NLM     Status:  MEDLINE    
Cardiac adenosine is formed both by an oxygen-sensitive (AMP----adenosine) and by an oxygen-insensitive (S-adenosylhomocysteine----adenosine) pathway. The phasic adenosine release during beta-adrenergic stimulation with isoproterenol is closely linked to coronary venous PO2 (isolated heart) and can be almost fully prevented when diastolic aortic pressure is maintained constant (heart in situ). During pressure autoregulation the transmural gradient of free adenosine is only increased when the autoregulatory reserve is exhausted. The critical PO2 below which adenosine formation is enhanced was found to be 3 mm Hg (isolated cardiomyocytes). Collectively, these data indicate that the formation of adenosine is not primarily coupled to the energy expenditure of the heart but to the supply/demand ratio for oxygen.
J Schrader; A Deussen; R T Smolenski
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Experientia     Volume:  46     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-01-24     Completed Date:  1991-01-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1172-5     Citation Subset:  IM    
Department of Physiology, Heinrich-Heine-University, Düsseldorf, Federal Republic of Germany.
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MeSH Terms
Adenosine / metabolism*
Coronary Circulation*
Energy Metabolism
Myocardium / metabolism*
Oxygen / metabolism*
S-Adenosylhomocysteine / metabolism
Reg. No./Substance:
58-61-7/Adenosine; 7782-44-7/Oxygen; 979-92-0/S-Adenosylhomocysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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