| Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity. | |
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MedLine Citation:
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PMID: 20190967 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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For many years the neuromodulator adenosine has been recognized as an endogenous anticonvulsant molecule and termed a "retaliatory metabolite." As the core molecule of ATP, adenosine forms a unique link between cell energy and neuronal excitability. In parallel, a ketogenic (high-fat, low-carbohydrate) diet is a metabolic therapy that influences neuronal activity significantly, and ketogenic diets have been used successfully to treat medically-refractory epilepsy, particularly in children, for decades. To date the key neural mechanisms underlying the success of dietary therapy are unclear, hindering development of analogous pharmacological solutions. Similarly, adenosine receptor-based therapies for epilepsy and myriad other disorders remain elusive. In this review we explore the physiological regulation of adenosine as an anticonvulsant strategy and suggest a critical role for adenosine in the success of ketogenic diet therapy for epilepsy. While the current focus is on the regulation of adenosine, ketogenic metabolism and epilepsy, the therapeutic implications extend to acute and chronic neurological disorders as diverse as brain injury, inflammatory and neuropathic pain, autism and hyperdopaminergic disorders. Emerging evidence for broad clinical relevance of the metabolic regulation of adenosine will be discussed. |
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Authors:
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S A Masino; M Kawamura; C D Wasser; C A Wasser; L T Pomeroy; D N Ruskin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current neuropharmacology Volume: 7 ISSN: 1875-6190 ISO Abbreviation: Curr Neuropharmacol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-06-18 Revised Date: 2011-06-06 |
Medline Journal Info:
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Nlm Unique ID: 101157239 Medline TA: Curr Neuropharmacol Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 257-68 Citation Subset: - |
Affiliation:
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Psychology Department, Trinity College, 300 Summit St., Hartford, CT, USA. susan.masino@trincoll.edu |
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| Comments/Corrections | |
Erratum In:
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Curr Neuropharmacol. 2010 Mar;8(1):81 Note: Wasser, C A [corrected to Wasser, C D] |
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