| Adenosine induces G2/M cell-cycle arrest by inhibiting cell mitosis progression. | |
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MedLine Citation:
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PMID: 19947935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cellular adenosine accumulates under stress conditions. Few papers on adenosine are concerned with its function in the cell cycle. The cell cycle is the essential mechanism by which all living things reproduce and the target machinery when cells encounter stresses, so it is necessary to examine the relationship between adenosine and the cell cycle. In the present study, adenosine was found to induce G-2/M cell-cycle arrest. Furthermore, adenosine was found to modulate the expression of some important proteins in the cell cycle, such as cyclin B and p21, and to inhibit the transition of metaphase to anaphase in mitosis. |
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Authors:
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Kun-Zhi Jia; Bo Tang; Lu Yu; Wei Cheng; Rong Zhang; Jian-Fa Zhang; Zi-Chun Hua |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-16 |
Journal Detail:
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Title: Cell biology international Volume: 34 ISSN: 1095-8355 ISO Abbreviation: Cell Biol. Int. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-05-04 Revised Date: 2010-11-12 |
Medline Journal Info:
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Nlm Unique ID: 9307129 Medline TA: Cell Biol Int Country: England |
Other Details:
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Languages: eng Pagination: 49-52 Citation Subset: IM |
Affiliation:
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Jiangsu Center of Hepatobiliary Diseases, State Key Laboratory of Pharmaceutical Biotechnology, Affiliated Gulou Hospital, Nanjing University, Nanjing 210093, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology* Anaphase Cell Division Cell Line Cyclin B / metabolism Cyclin-Dependent Kinase Inhibitor p21 / metabolism Flow Cytometry G2 Phase Humans Metaphase Microscopy, Fluorescence Mitosis* |
| Chemical | |
Reg. No./Substance:
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0/Cyclin B; 0/Cyclin-Dependent Kinase Inhibitor p21; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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