| Adenosine-induced cardiac arrest and EEG changes in patients with thoracic aorta endovascular repair. | |
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MedLine Citation:
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PMID: 16415312 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We studied haemodynamic and metabolic variables, and cerebral function after cardiac arrest induced by high dose of adenosine in patients undergoing thoracic aorta endovascular repair. METHODS: Arterial blood pressure, blood gas values and EEG were recorded continuously in 15 patients undergoing anaesthesia (isoflurane) for endovascular thoracic aorta repair. Cardiac arrest was induced by different doses of adenosine (Adrekar, Sanofi-Synthelabo, Berlin, Germany; 0.4-1.8 mg kg(-1) body weight). Serum concentrations of neurone-specific enolase (NSE) were determined before and after stent graft implantation. Neurological function was assessed before and after surgery. RESULTS: After adenosine, the heart beat stopped immediately for 18-58 s in close relation to the adenosine dose. EEG power was significantly reduced to -57%, but reached normal values within 5 min after cardiac arrest. In particular, the fast alpha- and beta-EEG-frequencies sensitively reflected patients' EEG activity during the procedure. No intraoperative increases in NSE concentrations, and no neurological dysfunctions after surgery, were observed. CONCLUSION: After adenosine-induced cardiac arrest, changes in haemodynamic variables and EEG power spectra reversed completely within 1 and 5 min, respectively, without persistent brain dysfunction after stent graft implantation. |
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Authors:
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K Plaschke; D Böckler; D Boeckler; H Schumacher; E Martin; H J Bardenheuer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-01-16 |
Journal Detail:
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Title: British journal of anaesthesia Volume: 96 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-09 Completed Date: 2006-03-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 310-6 Citation Subset: IM |
Affiliation:
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Clinic of Anaesthesiology, University of Heidelberg, Germany. konstanze.plaschke@med.uni-heidelberg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology* Adult Aged Aged, 80 and over Aneurysm, Dissecting / surgery Aortic Aneurysm, Thoracic / surgery* Blood Vessel Prosthesis Implantation / methods* Brain / drug effects, physiopathology Carbon Dioxide / blood Dose-Response Relationship, Drug Electroencephalography / drug effects Female Heart Arrest, Induced / methods* Hemodynamics Humans Intraoperative Period Male Middle Aged Monitoring, Intraoperative / methods Oxygen / blood Partial Pressure Stents Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 124-38-9/Carbon Dioxide; 58-61-7/Adenosine; 7782-44-7/Oxygen |
| Comments/Corrections | |
Erratum In:
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Br J Anaesth. 2006 Apr;96(4):545 Note: Boeckler, D [corrected to Böckler, D] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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