Document Detail


Adenosine increases total venous capacitance in awake instrumented rats.
MedLine Citation:
PMID:  1381768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the effect of adenosine on the venous system, mean circulatory filling pressure (MCFP) was determined during infusion of intravenous (i.v.) adenosine (66.5 to a maximum of 532 microgram.kg-1.min-1) in 9 awake instrumented rats before and during ganglionic blockade with i.v. hexamethonium, 0.6 mg.kg-1.min-1. MCFP, the equilibrated pressure (mm Hg) occurring when the circulation is arrested by transient inflation of a balloon in the right atrium, is inversely related to total venous capacitance. Both adenosine and hexamethonium caused a reduction in mean arterial pressure (MAP); heart rate (HR) decreased during adenosine infusion in the blocked, but not the unblocked, state. In the unblocked state, baseline MCFP was 6.5 +/- 0.3 mmHg; hexamethonium caused baseline MCFP to decrease to 5.3 +/- 0.3 mm Hg. In both the unblocked and the blocked state, adenosine caused a dose-related decrease in MCFP [6.5 +/- 0.3 to 5.5 +/- 0.6 mm Hg (532 microgram.kg-1.min-1 adenosine dose) unblocked state; and 5.3 +/- 0.3 to 4.3 +/- 0.3 mm Hg (400 microgram.kg-1.min-1 adenosine dose) blocked state]. This decrease in MCFP induced by adenosine was highly significant. Intravenous adenosine, in an awake instrumented rat model, increases venous capacitance, with and without ganglionic blockade.
Authors:
M R Glick; J D Gehman; J A Gascho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  19     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-10-13     Completed Date:  1992-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  709-13     Citation Subset:  IM    
Affiliation:
Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / administration & dosage,  pharmacology
Adenosine / administration & dosage,  pharmacology*
Animals
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Heart Arrest / chemically induced
Heart Rate / drug effects*
Hexamethonium
Hexamethonium Compounds / administration & dosage,  pharmacology*
Infusions, Intravenous
Male
Muscle Relaxation / drug effects
Rats
Rats, Inbred Strains
Veins / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Hexamethonium Compounds; 51-84-3/Acetylcholine; 58-61-7/Adenosine; 60-26-4/Hexamethonium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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