| Adenosine increases total venous capacitance in awake instrumented rats. | |
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MedLine Citation:
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PMID: 1381768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the effect of adenosine on the venous system, mean circulatory filling pressure (MCFP) was determined during infusion of intravenous (i.v.) adenosine (66.5 to a maximum of 532 microgram.kg-1.min-1) in 9 awake instrumented rats before and during ganglionic blockade with i.v. hexamethonium, 0.6 mg.kg-1.min-1. MCFP, the equilibrated pressure (mm Hg) occurring when the circulation is arrested by transient inflation of a balloon in the right atrium, is inversely related to total venous capacitance. Both adenosine and hexamethonium caused a reduction in mean arterial pressure (MAP); heart rate (HR) decreased during adenosine infusion in the blocked, but not the unblocked, state. In the unblocked state, baseline MCFP was 6.5 +/- 0.3 mmHg; hexamethonium caused baseline MCFP to decrease to 5.3 +/- 0.3 mm Hg. In both the unblocked and the blocked state, adenosine caused a dose-related decrease in MCFP [6.5 +/- 0.3 to 5.5 +/- 0.6 mm Hg (532 microgram.kg-1.min-1 adenosine dose) unblocked state; and 5.3 +/- 0.3 to 4.3 +/- 0.3 mm Hg (400 microgram.kg-1.min-1 adenosine dose) blocked state]. This decrease in MCFP induced by adenosine was highly significant. Intravenous adenosine, in an awake instrumented rat model, increases venous capacitance, with and without ganglionic blockade. |
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Authors:
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M R Glick; J D Gehman; J A Gascho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 19 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1992 May |
Date Detail:
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Created Date: 1992-10-13 Completed Date: 1992-10-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 709-13 Citation Subset: IM |
Affiliation:
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Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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administration & dosage,
pharmacology Adenosine / administration & dosage, pharmacology* Animals Blood Pressure / drug effects* Dose-Response Relationship, Drug Heart Arrest / chemically induced Heart Rate / drug effects* Hexamethonium Hexamethonium Compounds / administration & dosage, pharmacology* Infusions, Intravenous Male Muscle Relaxation / drug effects Rats Rats, Inbred Strains Veins / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Hexamethonium Compounds; 51-84-3/Acetylcholine; 58-61-7/Adenosine; 60-26-4/Hexamethonium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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