Document Detail


Adenosine and gastrointestinal inflammation.
MedLine Citation:
PMID:  23296303     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nucleosides such as adenosine (Ado) influence nearly every aspect of physiology and pathophysiology. Extracellular nucleotides liberated at local sites of inflammation are metabolized through regulated phosphohydrolysis by a series of ecto-nucleotidases including ectonucleoside triphosphate diphosphohydrolase-1 (CD39) and ecto-5'-nucleotidase (CD73), found on the surface of a variety of cell types. Once generated, Ado is made available to bind and activate one of four G protein-coupled Ado receptors. Recent in vitro and in vivo studies implicate Ado in a broad array of tissue-protective mechanisms that provide new insight into adenosine actions. Studies in cultured cells and murine tissues have indicated that Ado receptors couple to novel posttranslational protein modifications, including Cullin deneddylation, as a new anti-inflammatory mechanism. Studies in Ado receptor-null mice have been revealing and indicate a particularly important role for the Ado A2B receptor in animal models of intestinal inflammation. Here, we review contributions of Ado to cell and tissue stress responses, with a particular emphasis on the gastrointestinal mucosa.
Authors:
Sean P Colgan; Blair Fennimore; Stefan F Ehrentraut
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-08
Journal Detail:
Title:  Journal of molecular medicine (Berlin, Germany)     Volume:  91     ISSN:  1432-1440     ISO Abbreviation:  J. Mol. Med.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-30     Completed Date:  2013-07-30     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9504370     Medline TA:  J Mol Med (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine / physiology*
Animals
Gastrointestinal Diseases / physiopathology*
Humans
Inflammation
Intestinal Mucosa / physiology*
Grant Support
ID/Acronym/Agency:
DK095491/DK/NIDDK NIH HHS; DK50189/DK/NIDDK NIH HHS; HL60569/HL/NHLBI NIH HHS; R01 DK095491/DK/NIDDK NIH HHS; R01 HL060569/HL/NHLBI NIH HHS; R37 DK050189/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
K72T3FS567/Adenosine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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