| Adenosine does not save the heart of anoxia-tolerant vertebrates during prolonged oxygen deprivation. | |
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MedLine Citation:
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PMID: 17433747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite adenosine being regarded as an important signaling molecule capable of coordinating ATP supply and demand during periods of oxygen deprivation in anoxia-intolerant mammals, the importance of adenosinergic cardiovascular control in anoxia-tolerant vertebrates is poorly understood. Here, we report on adenosinergic cardiovascular control during normoxia and prolonged (hours to days) oxygen deprivation for three vertebrate species tolerant of severe hypoxia/anoxia, the closely related common (Cyprinus carpio) and crucian (Carassius carassius) carp, and the freshwater turtle (Trachemys scripta). Using an intra-arterial injection of the non-specific adenosine receptor antagonist aminophylline while measuring cardiac output (Q), heart rate (f(H)) and arterial blood pressure, we establish that adenosinergic cardiovascular control is unimportant during prolonged anoxia in the freshwater turtle (6 h at 21 degrees C and 14 d at 5 degrees C) and the crucian carp (5 d at 8 degrees C). In contrast, adenosinergic control contributes to the down-regulation of cardiac activity exhibited by 5 degrees C-acclimated common carp during a 12.5 h severe hypoxia (<0.3 mg O2 l(-1)) exposure. Specifically, aminophylline injection resulted in significant increases in f(H) and Q, and a decrease in total peripheral resistance. These species-specific differences in adenosinergic cardiovascular control during prolonged periods of oxygen deprivation may be related to differences displayed by these three species in their anoxia tolerance and survival strategies. |
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Authors:
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Jonathan A W Stecyk; Kåre-Olav Stensløkken; Göran E Nilsson; Anthony P Farrell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-12 |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Volume: 147 ISSN: 1095-6433 ISO Abbreviation: Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-06-05 Completed Date: 2007-08-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9806096 Medline TA: Comp Biochem Physiol A Mol Integr Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 961-73 Citation Subset: IM |
Affiliation:
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Department of Zoology, University of British Columbia, Vancouver, BC, Canada, V6T 1Z4. jonathan.stecyk@imbv.uio.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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drug effects* Adenosine / pharmacology* Aminophylline / pharmacology Animals Anoxia / physiopathology* Cardiovascular Physiological Phenomena / drug effects Carps / physiology Heart / drug effects* Injections Sodium Chloride / pharmacology Time Factors Turtles / physiology Vertebrates / physiology* |
| Chemical | |
Reg. No./Substance:
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317-34-0/Aminophylline; 58-61-7/Adenosine; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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