Document Detail


Adenosine deaminase in pleural fluids. Test for diagnosis of tuberculous pleural effusion.
MedLine Citation:
PMID:  6602695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adenosine deaminase (ADA) activity was studied in 221 patients with pleuroperitoneal effusions. Patients were subdivided into the following six groups: (1) 48 cases of tuberculosis; (2) 46 with malignancies; (3) 30 postpneumonic effusions; (4) 19 cases of several diseases; (5) 18 patients with pleural effusions of unknown origin; and (6) 60 with acellular transudates. Mean ADA activity was 92.43 +/- 29.43 U/L 37 degrees C in group 1; 13.43 +/- 10.69 in group 2; 19.91 +/- 19.64 in group 3; 14.27 +/- 17.47 in group 4; 14.48 +/- 13.92 in group 5; and 2.29 +/- 3.4 in group 6. Comparing the level achieved in group 1 with all others, the difference is significant at the p less than 0.001 level. Specificity (0.97) and sensitivity (1) of the test in tuberculosis is very high, when a value of more than 45 U/L is considered. In patients with pleural tuberculosis, T-lymphocytes predominate in the fluid but their number did not correlate with ADA-activity (p greater than 0.10). Assessment of ADA in pathologic fluids is of great value in the diagnosis of tuberculosis of the pleura.
Authors:
I Ocaña; J M Martinez-Vazquez; R M Segura; T Fernandez-De-Sevilla; J A Capdevila
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  84     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-3     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Deaminase / analysis*
Humans
Nucleoside Deaminases / analysis*
Pleural Effusion / enzymology*,  etiology
T-Lymphocytes / enzymology
Tuberculosis, Pleural / diagnosis*
Chemical
Reg. No./Substance:
EC 3.5.4.-/Nucleoside Deaminases; EC 3.5.4.4/Adenosine Deaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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