Document Detail


Adenosine deaminase attenuates canine coronary vasodilation during systemic hypoxia.
MedLine Citation:
PMID:  3963215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypothesis that adenosine mediates the coronary vasodilatory response to hypoxia was tested by determining if intracoronary infusion of the adenosine degrading enzyme, adenosine deaminase (ADA), would attenuate this response. Efficacy of ADA was also evaluated by examining its effect on the coronary responses to exogenous adenosine and to 20-s myocardial ischemia. Experiments were conducted in 14 anesthetized, open-chest dogs ventilated 3-5 min with 3% O2-5% CO2-92% N2 to induce systemic hypoxia. Under control, pre-ADA conditions, hypoxia (arterial PO2 19 +/- 2 mmHg) caused left anterior descending (LAD) coronary blood flow to increase from 100 +/- 12 to 382 +/- 47 ml X min-1 X 100 g-1 (+282%). After infusion of ADA (5 U X kg-1 X min-1 for 8-10 min) into the LAD, equally severe hypoxia (arterial PO2 18 +/- 3 mmHg) caused a significantly smaller increase in LAD flow, 79 +/- 9 to 234 +/- 41 ml X min-1 X 100 g-1 (+195%). Oxygen consumption in the LAD perfusion field was unchanged by hypoxia before ADA but fell significantly during hypoxia after ADA. ADA also attenuated significantly the coronary vasodilatory response to exogenous adenosine and to 20-s ischemia. The results of this investigation demonstrate a significant role of adenosine in the coronary vasodilatory response to systemic hypoxia.
Authors:
G F Merrill; H F Downey; C E Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  250     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-05-13     Completed Date:  1986-05-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H579-83     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adenosine / pharmacology,  physiology*
Adenosine Deaminase / pharmacology*
Animals
Anoxia / physiopathology*
Blood Gas Analysis
Coronary Circulation*
Coronary Disease / physiopathology
Dogs
Female
Hemodynamics
Male
Myocardium / metabolism
Nucleoside Deaminases / pharmacology*
Oxygen Consumption
Regional Blood Flow
Vasodilation
Grant Support
ID/Acronym/Agency:
HL-21657/HL/NHLBI NIH HHS; HL-29232/HL/NHLBI NIH HHS; HL-35027/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
58-61-7/Adenosine; EC 3.5.4.-/Nucleoside Deaminases; EC 3.5.4.4/Adenosine Deaminase

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