Document Detail

Adenosine deaminase activity in patients with renal adenocarcinoma.
MedLine Citation:
PMID:  890659     Owner:  NLM     Status:  MEDLINE    
Erythrocyte and lymphocyte adenosine deaminase (ADA) levels were studied in 31 patients with renal cell carcinoma (RCC). Decreased lymphocyte ADA levels occurred in patients with RCC. Erythrocyte ADA levels were reduced only in blood type B and O patients. Nephrectomy resulted in a rise in lymphocyte and erythrocyte ADA levels. Progression of clinical disease was associated with a fall in lymphocyte ADA values in all patients and with a rise in erythrocyte levels only in blood type A patients. Our results suggest that changes in erythrocyte and lymphocyte ADA levels in RCC patients are acquired and may offer insight into host-tumor interactions.
G Sufrin; G L Tritsch; A Mittelman; R H Moore; G P Murphy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  40     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-10-20     Completed Date:  1977-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  796-802     Citation Subset:  AIM; IM    
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MeSH Terms
ABO Blood-Group System
Adenocarcinoma / blood,  enzymology*,  pathology,  surgery
Adenosine Deaminase / metabolism*
Erythrocytes / enzymology
Kidney Neoplasms / blood,  enzymology*,  pathology,  surgery
Lymphocytes / enzymology
Middle Aged
Nucleoside Deaminases / metabolism*
Reg. No./Substance:
0/ABO Blood-Group System; EC 3.5.4.-/Nucleoside Deaminases; EC Deaminase

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