Document Detail


Adenosine contributes to hypoxia-induced forearm vasodilation in humans.
MedLine Citation:
PMID:  10601170     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In humans, hypoxia leads to increased sympathetic neural outflow to skeletal muscle. However, blood flow increases in the forearm. The mechanism of hypoxia-induced vasodilation is unknown. To test whether hypoxia-induced vasodilation is cholinergically mediated or is due to local release of adenosine, normal subjects were studied before and during acute hypoxia (inspired O(2) 10.5%; approximately 20 min). In experiment I, aminophylline (50-200 microg. min(-1). 100 ml forearm tissue(-1)) was infused into the brachial artery to block adenosine receptors (n = 9). In experiment II, cholinergic vasodilation was blocked by atropine (0.4 mg over 4 min) infused into the brachial artery (n = 8). The responses of forearm blood flow (plethysmography) and forearm vascular resistance to hypoxia in the infused and opposite (control) forearms were compared. During hypoxia (arterial O(2) saturation 77 +/- 2%), minute ventilation and heart rate increased while arterial pressure remained unchanged; forearm blood flow rose by 35 +/- 6% in the control forearm but only by 5 +/- 8% in the aminophylline-treated forearm (P < 0.02). Accordingly, forearm vascular resistance decreased by 29 +/- 5% in the control forearm but only by 9 +/- 6% in the aminophylline-treated forearm (P < 0.02). Atropine did not attenuate forearm vasodilation during hypoxia. These data suggest that adenosine contributes to hypoxia-induced vasodilation, whereas cholinergic vasodilation does not play a role.
Authors:
U A Leuenberger; K Gray; M D Herr
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  87     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2218-24     Citation Subset:  IM    
Affiliation:
Section of Cardiology, Department of Medicine, The Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA. uleuenberger@psghs.edu
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MeSH Terms
Descriptor/Qualifier:
Adenosine / physiology*
Adult
Aminophylline / pharmacology
Anoxia / physiopathology*
Atropine / pharmacology
Forearm / blood supply*
Hemodynamics
Humans
Male
Regional Blood Flow
Respiration
Vascular Resistance / drug effects
Vasodilation / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
HL02654/HL/NHLBI NIH HHS; M01RR10732/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
317-34-0/Aminophylline; 51-55-8/Atropine; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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