Document Detail

Adenosine amine congener mitigates noise-induced cochlear injury.
MedLine Citation:
PMID:  20806018     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Hearing loss from noise exposure is a leading occupational disease, with up to 5% of the population at risk world-wide. Here, we present a novel purine-based pharmacological intervention that can ameliorate noise-induced cochlear injury. Wistar rats were exposed to narrow-band noise (8-12 kHz, 110 dB SPL, 2-24 h) to induce cochlear damage and permanent hearing loss. The selective adenosine A(1) receptor agonist, adenosine amine congener (ADAC), was administered intraperitoneally (100 microg/kg/day) at time intervals after noise exposure. Hearing thresholds were assessed using auditory brainstem responses and the hair cell loss was evaluated by quantitative histology. Free radical damage in the organ of Corti was assessed using nitrotyrosine immunohistochemistry. The treatment with ADAC after noise exposure led to a significantly greater recovery of hearing thresholds compared with controls. These results were upheld by increased survival of sensory hair cells and reduced nitrotyrosine immunoreactivity in ADAC-treated cochlea. We propose that ADAC could be a valuable treatment for noise-induced cochlear injury in instances of both acute and extended noise exposures.
Srdjan M Vlajkovic; Kyu-Hyun Lee; Ann Chi Yan Wong; Cindy X Guo; Rita Gupta; Gary D Housley; Peter R Thorne
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Publication Detail:
Type:  Journal Article     Date:  2010-06-30
Journal Detail:
Title:  Purinergic signalling     Volume:  6     ISSN:  1573-9546     ISO Abbreviation:  Purinergic Signal.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-08-31     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101250499     Medline TA:  Purinergic Signal     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  273-81     Citation Subset:  -    
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MeSH Terms
Grant Support
G29//Action on Hearing Loss

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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