| Adenosine Deaminase Activity in Pleural Effusions of Lymphoma Patients. | |
MedLine Citation:
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PMID: 24854180 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND AIM: The purpose of this study was to assess the relationship of pleural-ADA (P-ADA) and non-Hodgkin's lymphoma (NHL). DESIGN AND METHODS: We retrospectively analyzed 63 NHL patients with pleural effusions who accepted a diagnostic thoracentesis, and who had P-ADA available at the China Medical University Hospital (Taichung, Taiwan) between January 2003 and April 2012. RESULTS THERE WERE 46 EXUDATES 40 MALIGNANT PLEURAL EFFUSIONS MPE, 5 COMPLICATED PARAPNEUMONIC EFFUSIONS, AND 1 UNDIAGNOSED EFFUSION AND 17 TRANSUDATES THE P-ADA ACTIVITY WAS SIGNIFICANTLY DIFFERENT BETWEEN THE TWO GROUPS P< 0005 AMONGST 40 MPE CASES, 29 WERE DUE TO B-CELL AND 11 DUE TO T-CELL NHL THERE WAS NO PLEURAL TRANSUDATIVE EFFUSION WITH P-ADA VALUE HIGHER THAN 26 U/L IN OUR STUDY, BUT SIMULTANEOUSLY 48% 22/46 OF EXUDATIVE PLEURAL EFFUSIONS SHOWED A P-ADA VALUE UNDER THAT CUT-OFF POINT: The P-ADA level reached the diagnostic cut-off for tuberculosis (40 IU/L) in 11 cases of MPE (11/40 = 27.5%): 9 B-cell NHL (9/29 = 31%) and 2 T-cell NHL (2/11 = 18%). The median levels (25th, 75th percentiles) of P-ADA were 28 IU/L (14-50) in the MPE of B-cell NHL and 26 IU/L (14-28) in the T-cell NHL (P = 0.693). CONCLUSIONS: The use of P-ADA in NHL effusion could aid the separation of transudates from exudates. Around one quarter MPE of NHL had abnormal P-ADA (>40 IU/L). There was no difference in the P-ADA activity in T-cell and B-cell NHL. |
Authors:
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Chih-Wei Yao; Biing-Ru Wu; Kuo-Yang Huang; Hung-Jen Chen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2014-5-22 |
Journal Detail:
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Title: QJM : monthly journal of the Association of Physicians Volume: - ISSN: 1460-2393 ISO Abbreviation: QJM Publication Date: 2014 May |
Date Detail:
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Created Date: 2014-5-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9438285 Medline TA: QJM Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© Crown copyright 2014. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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