Document Detail


Adenosine Deaminase Activity in Pleural Effusions of Lymphoma Patients.
MedLine Citation:
PMID:  24854180     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND AIM: The purpose of this study was to assess the relationship of pleural-ADA (P-ADA) and non-Hodgkin's lymphoma (NHL).
DESIGN AND METHODS: We retrospectively analyzed 63 NHL patients with pleural effusions who accepted a diagnostic thoracentesis, and who had P-ADA available at the China Medical University Hospital (Taichung, Taiwan) between January 2003 and April 2012. RESULTS THERE WERE 46 EXUDATES 40 MALIGNANT PLEURAL EFFUSIONS MPE, 5 COMPLICATED PARAPNEUMONIC EFFUSIONS, AND 1 UNDIAGNOSED EFFUSION AND 17 TRANSUDATES THE P-ADA ACTIVITY WAS SIGNIFICANTLY DIFFERENT BETWEEN THE TWO GROUPS P< 0005 AMONGST 40 MPE CASES, 29 WERE DUE TO B-CELL AND 11 DUE TO T-CELL NHL THERE WAS NO PLEURAL TRANSUDATIVE EFFUSION WITH P-ADA VALUE HIGHER THAN 26 U/L IN OUR STUDY, BUT SIMULTANEOUSLY 48% 22/46 OF EXUDATIVE PLEURAL EFFUSIONS SHOWED A P-ADA VALUE UNDER THAT CUT-OFF POINT: The P-ADA level reached the diagnostic cut-off for tuberculosis (40 IU/L) in 11 cases of MPE (11/40 = 27.5%): 9 B-cell NHL (9/29 = 31%) and 2 T-cell NHL (2/11 = 18%). The median levels (25th, 75th percentiles) of P-ADA were 28 IU/L (14-50) in the MPE of B-cell NHL and 26 IU/L (14-28) in the T-cell NHL (P = 0.693).
CONCLUSIONS: The use of P-ADA in NHL effusion could aid the separation of transudates from exudates. Around one quarter MPE of NHL had abnormal P-ADA (>40 IU/L). There was no difference in the P-ADA activity in T-cell and B-cell NHL.
Authors:
Chih-Wei Yao; Biing-Ru Wu; Kuo-Yang Huang; Hung-Jen Chen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-22
Journal Detail:
Title:  QJM : monthly journal of the Association of Physicians     Volume:  -     ISSN:  1460-2393     ISO Abbreviation:  QJM     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438285     Medline TA:  QJM     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Crown copyright 2014.
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