Document Detail

Adenosine A1 receptors, KATP channels, and ischemic preconditioning in dogs.
MedLine Citation:
PMID:  8498546     Owner:  NLM     Status:  MEDLINE    
The objective of the present study was to characterize the role of adenosine in myocardial ischemic preconditioning in the canine heart. Preconditioning with 5 min of ischemia resulted in a marked reduction in infarct size after 60 min of left circumflex coronary artery occlusion and 5 h of reperfusion in barbital-anesthetized dogs compared with dogs that were not preconditioned (4.8 +/- 1.9 vs. 27.9 +/- 4.5%; P < 0.05). Pretreatment with either the nonselective adenosine receptor antagonist PD 115199 or the selective adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine blocked this protective effect, although in the absence of preconditioning neither of the antagonists affected infarct size. Intracoronary infusion of two different doses of adenosine or dipyridamole over a 5-min period before a prolonged 60-min occlusion period did not mimic preconditioning; however, intracoronary infusion of a combination of adenosine and dipyridamole produced a significant reduction in infarct size (13.6 +/- 4.1%), which was abolished by pretreatment with the ATP-dependent potassium (KATP) channel antagonist glibenclamide. These results suggest that activation of adenosine A1 receptors produces myocardial preconditioning in the canine heart by opening KATP channels.
J A Auchampach; G J Gross
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  264     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-21     Completed Date:  1993-06-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1327-36     Citation Subset:  IM    
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226.
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MeSH Terms
Adenosine / antagonists & inhibitors,  pharmacology
Adenosine Triphosphate / physiology*
Blood Glucose / analysis
Coronary Circulation / drug effects
Coronary Disease / metabolism*
Glyburide / pharmacology
Hemodynamics / drug effects
Myocardial Infarction / pathology
Myocardial Reperfusion*
Potassium Channels / metabolism*
Purines / pharmacology
Receptors, Purinergic / metabolism*
Sulfonamides / pharmacology
Xanthines / pharmacology
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Potassium Channels; 0/Purines; 0/Receptors, Purinergic; 0/Sulfonamides; 0/Xanthines; 102146-07-6/1,3-dipropyl-8-cyclopentylxanthine; 10238-21-8/Glyburide; 107478-35-3/N-(2-(dimethylamino)ethyl)-N-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)benzenesulfonamide; 56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine

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