Document Detail

Adenosine A1 and A2A receptor cross-talk during ageing in the rat myocardium.
MedLine Citation:
PMID:  12915207     Owner:  NLM     Status:  MEDLINE    
Adenosine (Ado), a naturally occurring autacoid, exerts cardioprotective effects against myocardial ischemia and reperfusion injury, through activation of its receptors type 1 (A1) and 2A (A2A). Since ageing involves a complex change in these effects, we evaluated A1 and A2A gene expression in left (LV) and right ventricle (RV) from 2-, 5-, 12-, and 21-month-old Sprague-Dawley rats. LV end-diastolic (EDD) and end-systolic (ESD) internal dimensions (mm) and LV fractional shortening (FS, %) were measured by M-mode echocardiography. Senescence was associated with a reduction in FS (42+/-1, 38+/-2, 39+/-2 and 35+/-2, in 2-, 5-, 12- and 21-month-old rats; p<0.02) and increases in EDD (7.5+/-0.2, 8.1+/-0.2, 8.5+/-0.2 and 8.8+/-0.2; p<0.001) and ESD (4.2+/-0.1, 4.4+/-0.2, 4.7+/-0.2 and 5.1+/-0.2; p=0.002). Ado A1 mRNA levels were highest in 12 and 21-month-old animals in both ventricles (LV: p<0.001; RV: p=0.001). By contrast, Ado A2A gene expression was lower in the aged LV (p<0.001), but higher in the aged RV (p<0.001). These modifications of Ado receptor gene expression and especially the increase in A1 receptor mRNA may partially explain the stronger antiadrenergic effects of Ado in the senescent heart.
Beatrice Arosio; Stefano Perlini; Carmen Calabresi; Rossana Tozzi; Giuseppina Palladini; Alberto U Ferrari; Carlo Vergani; Giorgio Annoni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental gerontology     Volume:  38     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-13     Completed Date:  2003-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  855-61     Citation Subset:  IM    
Department of Internal Medicine and Gerontology, Ospedale Maggiore IRCCS, Cattedra di Geron. e Geriatria, Via Pace 9, 20122 Milan, Italy.
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MeSH Terms
Aging / physiology*
Gene Expression
Heart Ventricles
Myocardium / metabolism*
RNA, Messenger / analysis*
Rats, Sprague-Dawley
Receptor Cross-Talk / physiology*
Receptor, Adenosine A1 / genetics*
Receptor, Adenosine A2A / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/RNA, Messenger; 0/Receptor, Adenosine A1; 0/Receptor, Adenosine A2A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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