Document Detail

Adenosine 5'-triphosphate induced dilation of human coronary microvessels in vivo.
MedLine Citation:
PMID:  10361904     Owner:  NLM     Status:  MEDLINE    
OBJECT: This study was performed to compare the coronary microvascular response to adenosine 5'-triphosphate (ATP) with the response to adenosine in humans. METHODS: Coronary blood flow velocity was determined using a Doppler flow wire. After intracoronary nitroglycerin infusion, intracoronary bolus injections of adenosine (20 microg) and ATP (20 microg) were performed to induce reactive hyperemia. PATIENTS: Twenty-nine patients (23 men and 6 women, mean age: 63+/-9 years) with coronary artery disease and risk factors for coronary atherosclerosis were studied. RESULTS: Coronary flow reserve in response to ATP was similar to that for adenosine (2.7+/-0.7 vs. 2.7+/-0.7). However, the duration of ATP-induced vasodilation was longer than that of adenosine-induced dilation (39+/-25 seconds vs. 26+/-12 seconds, p<0.0001). The coronary flow reserve obtained with either ATP or adenosine was significantly reduced in the interventioned arteries compared with non-stenosed arteries. The coronary flow reserve obtained with ATP was similar to that obtained with adenosine in both artery groups. The duration of the vasodilator effect of ATP was significantly greater than that of adenosine in both artery groups. CONCLUSION: These results suggest that ATP induces maximal dilation of coronary microvessels, most likely through an endothelium-independent mechanism. The degradation of ATP to adenosine 5'-monophosphate (AMP) and adenosine, as well as the direct action of ATP on A2-adenosine receptors may be responsible for the dilation. We conclude that coronary flow reserve can be determined safely with intracoronary ATP administration.
M Kato; N Shiode; H Teragawa; H Hirao; T Yamada; T Yamagata; H Matsuura; G Kajiyama
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  38     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-29     Completed Date:  1999-07-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  324-9     Citation Subset:  IM    
First Department of Internal Medicine, Hiroshima University School of Medicine.
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MeSH Terms
Adenosine / pharmacology*
Adenosine Triphosphate / pharmacology*
Blood Flow Velocity / drug effects
Coronary Disease / physiopathology
Coronary Vessels / drug effects*
Hemodynamics / drug effects
Middle Aged
Vasodilation / drug effects*
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Vasodilator Agents; 56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine
Comment In:
Intern Med. 1999 Apr;38(4):305-6   [PMID:  10361900 ]

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