| Adenomyosis has no adverse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI. | |
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MedLine Citation:
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PMID: 20409633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To establish the effect of adenomyosis on IVF/ICSI outcomes in infertile patients with endometriosis who were pretreated with long-term (>/=3 months) GnRH-agonist prior to IVF/ICSI. STUDY DESIGN: Retrospective study in 74 infertile patients with surgically proven endometriosis who were treated with IVF/ICSI between January 2002 and March 2007. The diagnosis of adenomyosis was based on transvaginal ultrasound criteria. All patients were pretreated with long-term (>or=3 months) GnRH-agonist prior to IVF/ICSI. RESULTS: 90.4% of the patients were diagnosed with endometriosis rASRM stages III-IV. Adenomyosis was demonstrated in 27% of them and was predominantly located in the posterior wall of the uterus. The following IVF/ICSI outcomes were found: a mean duration of GnRH-agonist use prior to IVF/ICSI of 5.35 months (3-26); a mean dosage of FSH used of 208IU (75-450); the mean number of oocytes retrieved was 8.73 (1-30); the mean number of embryos obtained was 3.86 (0-16); the mean number of embryos transferred was 1.6; a mean fertilization rate of 43.6%; a mean implantation rate of 26.3%; a mean miscarriage rate of 24.3%; and a clinical pregnancy rate (fetal heart activity on ultrasound beyond 12 weeks of gestation) of 31.7%. No significant differences were found for any of the IVF/ICSI outcomes between women with and without adenomyosis. CONCLUSIONS: Adenomyosis had no adverse effects on IVF/ICSI outcomes in infertile women with proven endometriosis who were pretreated with long-term GnRH-agonist. |
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Authors:
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V Mijatovic; E Florijn; N Halim; R Schats; P Hompes |
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Publication Detail:
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Type: Journal Article Date: 2010-04-21 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 151 ISSN: 1872-7654 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 62-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Reproductive Medicine, Endometriosis Center VUmc, De Boelelaan 1117, 1081 HVAmsterdam, The Netherlands. mijatovic@vumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Down-Regulation Endometriosis / drug therapy*, ultrasonography Female Fertilization in Vitro* Gonadotropin-Releasing Hormone / agonists Humans Leuprolide / therapeutic use Ovulation Induction Pituitary Gland / drug effects Pregnancy Pregnancy Rate Retrospective Studies Sperm Injections, Intracytoplasmic* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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33515-09-2/Gonadotropin-Releasing Hormone; 53714-56-0/Leuprolide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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