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Adenoma-carcinoma sequence in intrahepatic cholangiocarcinoma.
MedLine Citation:
PMID:  22326450     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Cholangiocarcinoma is a rare tumor but recent data report a worldwide increase in incidence and mortality. There are several risk factors associated with cholangiocarcinoma, and chronic inflammation of billiary tree seems to be implied in the cholangiocarcinogenesis, but little is known about this process. PRESENTATION OF CASE: We present a 56-year-old female with a bile duct adenoma incidentally discovered in the follow up of breast cancer that 18 months later progress to intrahepatic cholangiocarcinoma. DISCUSSION: This is a rare presentation of intrahepatic cholangiocarcinoma that suggests the classic adenoma-carcinoma sequence in cholangiocarcinogenesis. Furthermore this case gives rise to some questions about the possible common ground on intrahepatic cholangiocarcinoma and breast cancer. CONCLUSION: Cholangiocarcinogenesis is a complex multi-step mechanism and further investigations are needed to fully understand this process.
Authors:
André Costa Pinho; Renato Bessa Melo; Manuel Oliveira; Marinho Almeida; Joanne Lopes; Luís Graça; J Costa-Maia
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-18
Journal Detail:
Title:  International journal of surgery case reports     Volume:  3     ISSN:  2210-2612     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-2-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101529872     Medline TA:  Int J Surg Case Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  131-133     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Hepatobiliary-pancreatic Unit, General Surgery Department, Hospital S. João, Alameda Prof. Hernâni Monteiro 4200-319, Portugal; Faculty of Medicine, University of Porto, Hospital S. João, Alameda Prof. Hernâni Monteiro 4200-319, Portugal.
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