Document Detail


Adenocarcinomas of the nasal cavity and paranasal sinuses: a clinicopathological and immunohistochemical study of 14 cases.
MedLine Citation:
PMID:  15330803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To evaluate the clinicopathological profile of 14 cases of nasal and paranasal sinusal adenocarcinoma, and to assess the usefulness of immunohistochemistry in the differential diagnosis of primary and metastatic intestinal-type adenocarcinoma. METHODS AND RESULTS: Fourteen cases of nasal and paranasal adenocarcinoma, treated at IPOFG, Lisbon, between 1976 and 2002, were studied. Clinical records were reviewed and expression of cytokeratin (CK)7 and CK20 and of neuroendocrine markers was evaluated. The male : female ratio was 3 : 1, and the mean age of the patients was 65.3 years. Ten cases occurred in the paranasal sinuses. There was a history of professional exposure to dust in three patients. Twelve cases were high-grade intestinal type adenocarcinomas (ITAC) and two were low-grade. CK7 was present in 2/9 ITAC cases and CK20 in 8/9 ITAC and in cases of mixed and mucinous histology. All high-grade cases showed neuroendocrine differentiation. Seven of the 12 patients with high-grade adenocarcinoma died of the disease, with a mean follow-up of 47.4 months. CONCLUSIONS: Nasal and paranasal adenocarcinoma mostly occurs in men in the 7th decade. ITAC is the most frequent histological type. The pattern of CK7/CK20 was not useful in the distinction between primary and metastatic intestinal adenocarcinoma. However, in the former, neuroendocrine differentiation proved to be a valuable tool in that distinction.
Authors:
J Abecasis; G Viana; C Pissarra; T Pereira; I Fonseca; J Soares
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  45     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-27     Completed Date:  2005-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  254-9     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Blackwell Publishing Limited
Affiliation:
Serviço Universitário de Anatomia Patológica, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / metabolism,  pathology*
Aged
Aged, 80 and over
Chromogranin A
Chromogranins / analysis
Female
Follow-Up Studies
Humans
Immunohistochemistry
Intermediate Filament Proteins / analysis
Keratin-20
Keratin-7
Keratin-8
Keratins / analysis
Male
Middle Aged
Nose Neoplasms / metabolism,  pathology*
Paranasal Sinus Neoplasms / metabolism,  pathology*
Synaptophysin / analysis
Chemical
Reg. No./Substance:
0/Chromogranin A; 0/Chromogranins; 0/Intermediate Filament Proteins; 0/KRT20 protein, human; 0/KRT7 protein, human; 0/KRT8 protein, human; 0/Keratin-20; 0/Keratin-7; 0/Keratin-8; 0/Synaptophysin; 68238-35-7/Keratins

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