Document Detail


Adenocarcinoma in columnar-lined Barrett's esophagus. Analysis of 13 esophagectomies.
MedLine Citation:
PMID:  4037198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
From 1977 to 1982, 13 patients with adenocarcinoma arising in the distal esophagus lined by columnar epithelium underwent esophagectomy with detailed analysis of the pathologic specimen. In three patients, microinvasive carcinoma was detected before dysplasia occurred. In five patients, the ectopic mucosa was discontinuous, prolonged cranially by islands of columnar epithelium scattered in the squamous mucosa. Variable degrees of dysplasia were found in the columnar epithelium in seven specimens in areas of intestinal metaplasia. In four patients with high-grade dysplasia, several foci of intramucosal carcinoma were identified. They were scattered over the whole length of the ectopic mucosa. These data strongly suggest that adenocarcinoma develops from dysplasia, the real premalignant lesion. Careful periodic screening must be carried out in patients identified as having Barrett's esophagus. Dysplasia may be detected and located by endoscopy with dye spraying with directed biopsies. Patients with high-grade dysplasia should undergo esophagectomy with resection of the whole ectopic mucosa because they are at high risk for development of carcinoma.
Authors:
E C Saubier; C Gouillat; C Samaniego; M Guillaud; B Moulinier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of surgery     Volume:  150     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-10-11     Completed Date:  1985-10-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / pathology*,  surgery
Adult
Aged
Barrett Esophagus / pathology*
Esophageal Diseases / pathology*
Esophageal Neoplasms / pathology*,  surgery
Esophagoscopy
Esophagus / pathology*,  surgery
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Mucous Membrane / pathology
Neoplasm Recurrence, Local
Precancerous Conditions
Reoperation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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