Document Detail

Adenocarcinoma in columnar-lined Barrett's esophagus. Analysis of 13 esophagectomies.
MedLine Citation:
PMID:  4037198     Owner:  NLM     Status:  MEDLINE    
From 1977 to 1982, 13 patients with adenocarcinoma arising in the distal esophagus lined by columnar epithelium underwent esophagectomy with detailed analysis of the pathologic specimen. In three patients, microinvasive carcinoma was detected before dysplasia occurred. In five patients, the ectopic mucosa was discontinuous, prolonged cranially by islands of columnar epithelium scattered in the squamous mucosa. Variable degrees of dysplasia were found in the columnar epithelium in seven specimens in areas of intestinal metaplasia. In four patients with high-grade dysplasia, several foci of intramucosal carcinoma were identified. They were scattered over the whole length of the ectopic mucosa. These data strongly suggest that adenocarcinoma develops from dysplasia, the real premalignant lesion. Careful periodic screening must be carried out in patients identified as having Barrett's esophagus. Dysplasia may be detected and located by endoscopy with dye spraying with directed biopsies. Patients with high-grade dysplasia should undergo esophagectomy with resection of the whole ectopic mucosa because they are at high risk for development of carcinoma.
E C Saubier; C Gouillat; C Samaniego; M Guillaud; B Moulinier
Related Documents :
3722408 - Prognostic importance of dna flow cytometry in non-hodgkin's lymphomas.
9137158 - The efficacy of open lung biopsy.
21173518 - Comparison of biomarkers for predicting disease severity and long-term respiratory prog...
6796168 - Recovery of bronchial epithelium on stopping smoking.
23539718 - Idiopathic adult growth hormone deficiency.
12478648 - Cystic appearance of cervical lymph nodes is characteristic of metastatic papillary thy...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of surgery     Volume:  150     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-10-11     Completed Date:  1985-10-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenocarcinoma / pathology*,  surgery
Barrett Esophagus / pathology*
Esophageal Diseases / pathology*
Esophageal Neoplasms / pathology*,  surgery
Esophagus / pathology*,  surgery
Lymphatic Metastasis
Middle Aged
Mucous Membrane / pathology
Neoplasm Recurrence, Local
Precancerous Conditions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Changes in bile salt composition after cholecystectomy and ileal resection.
Next Document:  Malignant tumors of the anus. A study of 106 cases.