Document Detail

Adenocarcinoma in Barrett mucosa treated by endoscopic mucosal resection.
MedLine Citation:
PMID:  19886713     Owner:  NLM     Status:  MEDLINE    
Adenocarcinoma and dysplasias are recognized complications of Barrett mucosa. In the past, the treatment for this carcinoma was esophagectomy. However, new techniques, including endoscopic mucosal resection, sometimes replace esophagectomy and are becoming standard procedures in clinical practice, not just in major medical centers. Pathologists must learn to handle these specimens, which have extensive artifacts. Also, Barrett mucosa has duplicated stromal layers beneath the mucosa that include a new lamina propria and a new muscularis mucosae. We must be aware of these peculiarities because of staging implications. Regardless of new technology, the diagnostic approach to dysplasia depends on the light microscopic interpretation, which is not as reliable or consistent as one would wish. Hopefully, better diagnostic criteria will arise, and perhaps a new histologic stain or a molecular or genetic test will emerge that complements "our eyeballs."
Henry D Appelman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  133     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1793-7     Citation Subset:  AIM; IM    
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
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MeSH Terms
Adenocarcinoma / pathology,  surgery*
Barrett Esophagus / pathology,  surgery*
Esophagoscopy / methods*
Middle Aged
Mucous Membrane / pathology,  surgery
Neoplasm Invasiveness
Precancerous Conditions / pathology,  surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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