Document Detail


Adenocarcinoma of the esophagogastric junction: incidence, characteristics, and treatment strategies.
MedLine Citation:
PMID:  20602191     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of adenocarcinoma of the esophagogastric junction (AEG) is dramatically increasing in Western countries, while it is not increasing in Eastern countries. Siewert type I tumors are observed less frequently in Eastern countries in comparison to Western countries. On the other hand, other clinicopathological features of AEG, including age, male-to-female ratio, pathological grade, tumor progression, and prognosis, are similar in Western and Eastern countries. Two surgical phase III trials have indicated that AEG type I should be treated surgically as esophageal cancer, while types II and III should be regarded as true gastric cancer. No phase III trials have demonstrated a significant interaction comparing hazard ratios for death between AEG and true gastric cancer in the subset analyses with regard to chemotherapy.
Authors:
Shinichi Hasegawa; Takaki Yoshikawa
Publication Detail:
Type:  Journal Article; Review     Date:  2010-07-03
Journal Detail:
Title:  Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association     Volume:  13     ISSN:  1436-3291     ISO Abbreviation:  Gastric Cancer     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886238     Medline TA:  Gastric Cancer     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  63-73     Citation Subset:  IM    
Affiliation:
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, 241-0815, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / epidemiology,  pathology,  therapy*
Clinical Trials, Phase III as Topic
Esophageal Neoplasms / epidemiology,  pathology,  therapy*
Esophagogastric Junction / pathology
Female
Humans
Incidence
Male
Prognosis
Stomach Neoplasms / epidemiology,  pathology,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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