Document Detail

Adenocarcinoma arising in a rectovaginal fistula in Crohn disease.
MedLine Citation:
PMID:  20736780     Owner:  NLM     Status:  MEDLINE    
Adenocarcinomas occurring in the vagina are rare. Their correct classification may be very challenging to both the gynecologist and the pathologist, but it is essential for appropriate therapy. Although most adenocarcinomas in the vagina arise from other sites in the female genital tract, a significant minority reflects metastasis from a colorectal site. We report a very unusual occurrence of an adenocarcinoma that presented as a mass in the vagina protruding through the introitus. It arose in a rectovaginal fistula consequent to chronic Crohn disease, but it did not extend to involve the colonic mucosa. Neither the initial clinical examination nor the pathologic examination suggested the correct diagnosis. We report this case to remind the gynecologists of the potential complications of Crohn disease, and to highlight for the pathologists the difficulty that is often encountered in the correct identification of the source of carcinomas that are found in the vagina.
Mary Chu; Henry Crist; Richard J Zaino
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  29     ISSN:  1538-7151     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-25     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  497-500     Citation Subset:  IM    
Department of Obstetrics and Gynecology, M.S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA.
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MeSH Terms
Adenocarcinoma / complications,  secondary*
Colorectal Neoplasms / complications,  pathology*
Crohn Disease / complications*,  pathology
Rectovaginal Fistula / complications*,  pathology
Vaginal Neoplasms / complications,  secondary*

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