| Adeno-associated virus is associated with a lower risk of high-grade cervical neoplasia. | |
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MedLine Citation:
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PMID: 11263951 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adeno-associated virus (AAV) is a ubiquitous human helper-dependent parvovirus which may interact with human papillomaviruses (HPV) to modify a woman's risk of cervical neoplasia. This analysis was nested in a cohort study of low-income women receiving Pap smears as part of their family planning services. We selected cases (55 with high-grade cervical squamous intraepithelial lesions (HSIL) and 162 with low-grade LSIL) and controls (96 women with normal cervical cytology) and analyzed cervical DNA for AAV, using PCR amplification/dot blot hybridization, and HPV, using hybrid capture I. AAV positivity was associated with a significantly reduced risk of HSIL (age and HPV-adjusted odds ratio (aOR) = 0.32) yet not with LSIL (aOR = 0.78); 53.8% of HSIL, 66.9% of LSIL, and 70.7% of controls were AAV+. AAV appears to interact with HPV to reduce SIL risk; relative to the HPV-/AAV+ exposure, the respective aORs for HSIL and HPV+/AAV-, HPV+/AAV+, and HPV-/AAV+ were 17.0, 6.9, and 3.5. AAV+ was not associated with age, race, HPV status, or sexual or reproductive risk factors. These results strongly suggest that AAV may play a protective or inhibitory role in late stage cervical carcinogenesis. This conclusion needs to be verified in additional epidemiologic studies. |
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Authors:
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A L Coker; R B Russell; S M Bond; L Pirisi; Y Liu; M Mane; N Kokorina; T Gerasimova; P L Hermonat |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experimental and molecular pathology Volume: 70 ISSN: 0014-4800 ISO Abbreviation: Exp. Mol. Pathol. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-26 Completed Date: 2001-04-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370711 Medline TA: Exp Mol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 83-9 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Academic Press. |
Affiliation:
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Department of Epidemiology and Biostatistics, School of Medicine, University of South Carolina, Columbia, 29204, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ambulatory Care Facilities Carcinoma, Squamous Cell / virology Case-Control Studies Cohort Studies DNA, Viral / analysis Dependovirus / genetics, isolation & purification* Female Humans Papillomaviridae / isolation & purification Polymerase Chain Reaction Risk Factors Socioeconomic Factors Uterine Cervical Neoplasms / virology* Vaginal Smears |
| Grant Support | |
ID/Acronym/Agency:
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AI-421207/AI/NIAID NIH HHS; R03CA73997/CA/NCI NIH HHS; R29CA57466/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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