Document Detail

Adenine nucleotide and phosphoenolpyruvate transport by bovine chromaffin granule "ghosts".
MedLine Citation:
PMID:  6621884     Owner:  NLM     Status:  MEDLINE    
Purified bovine adrenal chromaffin granule "ghosts" (resealed membranes) accumulate nucleotides and phosphoenolpyruvate in a temperature-dependent process. Equilibration takes several hours, the compounds being accumulated to not more than twice their concentration in the medium. This uptake occurs primarily by a non-saturable diffusion process, and rates and extents show little dependence on membrane energization. Uptake rates are inhibited less than 50% by compounds that discharge the "ghost" membrane potential, or by atractylate or low concentrations of Cibacron Blue. The data gave little support to the theory that chromaffin granules have a membrane potential-dependent adenine nucleotide transport process and that nucleotides are in equilibrium with the positive-inside potential across the granule membrane.
H A Grüninger; D K Apps; J H Phillips
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience     Volume:  9     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  917-24     Citation Subset:  IM    
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MeSH Terms
Adenine Nucleotides / metabolism*
Adenosine Diphosphate / metabolism
Adenosine Monophosphate / metabolism
Adenosine Triphosphate / metabolism
Adrenal Medulla / metabolism*
Biological Transport, Active
Chromaffin Granules / metabolism*
Chromaffin System / metabolism*
Energy Metabolism
Membrane Potentials
Phosphoenolpyruvate / metabolism*
Reg. No./Substance:
0/Adenine Nucleotides; 56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate; 73-89-2/Phosphoenolpyruvate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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