| Adenine, guanine and pyridine nucleotides in blood during physical exercise and restitution in healthy subjects. | |
| | |
MedLine Citation:
|
PMID: 20714766 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Maximal physical exertion is accompanied by increased degradation of purine nucleotides in muscles with the products of purine catabolism accumulating in the plasma. Thanks to membrane transporters, these products remain in an equilibrium between the plasma and red blood cells where they may serve as substrates in salvage reactions, contributing to an increase in the concentrations of purine nucleotides. In this study, we measured the concentrations of adenine nucleotides (ATP, ADP, AMP), inosine nucleotides (IMP), guanine nucleotides (GTP, GDP, GMP), and also pyridine nucleotides (NAD, NADP) in red blood cells immediately after standardized physical effort with increasing intensity, and at the 30th min of rest. We also examined the effect of muscular exercise on adenylate (guanylate) energy charge--AEC (GEC), and on the concentration of nucleosides (guanosine, inosine, adenosine) and hypoxanthine. We have shown in this study that a standardized physical exercise with increasing intensity leads to an increase in IMP concentration in red blood cells immediately after the exercise, which with a significant increase in Hyp concentration in the blood suggests that Hyp was included in the IMP pool. Restitution is accompanied by an increase in the ATP/ADP and ADP/AMP ratios, which indicates an increase in the phosphorylation of AMP and ADP to ATP. Physical effort applied in this study did not lead to changes in the concentrations of guanine and pyridine nucleotides in red blood cells. |
| | |
Authors:
|
W Dudzinska; A Lubkowska; B Dolegowska; K Safranow; K Jakubowska |
Related Documents
:
|
20887236 - Sorption of antimicrobial agents in blow-fill-seal packs. 10371446 - 31p mrs studies of exercising human muscle at high temporal resolution. 2584276 - Seizure-induced damage to substantia nigra and globus pallidus is accompanied by pronou... 11826176 - Low intensity exercise in humans accelerates mitochondrial atp production and pulmonary... 15472216 - Growth hormone treatment improves peripheral muscle oxygen extraction-utilization durin... 15670536 - Comparative efficacy of ranolazine versus atenolol for chronic angina pectoris. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-17 |
Journal Detail:
|
Title: European journal of applied physiology Volume: 110 ISSN: 1439-6327 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
|
Languages: eng Pagination: 1155-62 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Faculty of Natural Sciences, Szczecin University, Al. Piastów 40b, 71-065, Szczecin, Poland. wiola@univ.szczecin.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Risk of acquiring tick-borne infections in forestry workers from Lazio, Italy.
Next Document: Thermoregulatory responses to ice-slush beverage ingestion and exercise in the heat.