Document Detail


Adenine, guanine and pyridine nucleotides in blood during physical exercise and restitution in healthy subjects.
MedLine Citation:
PMID:  20714766     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maximal physical exertion is accompanied by increased degradation of purine nucleotides in muscles with the products of purine catabolism accumulating in the plasma. Thanks to membrane transporters, these products remain in an equilibrium between the plasma and red blood cells where they may serve as substrates in salvage reactions, contributing to an increase in the concentrations of purine nucleotides. In this study, we measured the concentrations of adenine nucleotides (ATP, ADP, AMP), inosine nucleotides (IMP), guanine nucleotides (GTP, GDP, GMP), and also pyridine nucleotides (NAD, NADP) in red blood cells immediately after standardized physical effort with increasing intensity, and at the 30th min of rest. We also examined the effect of muscular exercise on adenylate (guanylate) energy charge--AEC (GEC), and on the concentration of nucleosides (guanosine, inosine, adenosine) and hypoxanthine. We have shown in this study that a standardized physical exercise with increasing intensity leads to an increase in IMP concentration in red blood cells immediately after the exercise, which with a significant increase in Hyp concentration in the blood suggests that Hyp was included in the IMP pool. Restitution is accompanied by an increase in the ATP/ADP and ADP/AMP ratios, which indicates an increase in the phosphorylation of AMP and ADP to ATP. Physical effort applied in this study did not lead to changes in the concentrations of guanine and pyridine nucleotides in red blood cells.
Authors:
W Dudzinska; A Lubkowska; B Dolegowska; K Safranow; K Jakubowska
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-17
Journal Detail:
Title:  European journal of applied physiology     Volume:  110     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-22     Completed Date:  2011-03-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1155-62     Citation Subset:  IM    
Affiliation:
Department of Physiology, Faculty of Natural Sciences, Szczecin University, Al. Piastów 40b, 71-065, Szczecin, Poland. wiola@univ.szczecin.pl
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MeSH Terms
Descriptor/Qualifier:
Adenine / blood,  metabolism
Adenine Nucleotides / blood,  metabolism
Adult
Erythrocytes / chemistry,  metabolism
Exercise / physiology*
Guanine / blood,  metabolism
Guanine Nucleotides / blood,  metabolism
Health
Humans
Male
Purine Nucleotides / blood*,  metabolism
Pyridines / blood*,  metabolism
Rest / physiology*
Young Adult
Chemical
Reg. No./Substance:
0/Adenine Nucleotides; 0/Guanine Nucleotides; 0/Purine Nucleotides; 0/Pyridines; 73-24-5/Adenine; 73-40-5/Guanine
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