Document Detail

Adenine arabinoside in idoxuridine unresponsive and intolerant herpetic keratitis.
MedLine Citation:
PMID:  123413     Owner:  NLM     Status:  MEDLINE    
Twenty-two patients with active herpes simplex dendritic keratitis, in whom topical idoxuridine was unsuccessful in controlling their disease, were treated with topical adenine arabinoside (ara-A), a purine analogue effective against many DNA viruses. This drug was an effective antiviral agent in these patients. No signs of ocular or adnexal toxicity were noted.
R A Hyndiuk; D S Hull; R O Schultz; G N Chin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  79     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-06-02     Completed Date:  1975-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  655-8     Citation Subset:  AIM; IM    
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MeSH Terms
Adenine / analogs & derivatives
Administration, Topical
Anti-Inflammatory Agents / adverse effects
Antiviral Agents / administration & dosage,  adverse effects,  therapeutic use*
Arabinose / analogs & derivatives
Drug Eruptions
Drug Evaluation
Idoxuridine / adverse effects,  therapeutic use*
Keratitis, Dendritic / drug therapy*
Purine Nucleosides / administration & dosage,  adverse effects,  therapeutic use*
Time Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antiviral Agents; 0/Glucocorticoids; 0/Ointments; 0/Purine Nucleosides; 147-81-9/Arabinose; 54-42-2/Idoxuridine; 73-24-5/Adenine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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