| Adefovir dipivoxil monotherapy and combination therapy with lamivudine for the treatment of chronic hepatitis B in an Asian population. | |
| | |
MedLine Citation:
|
PMID: 17503746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To determine differences in Chinese patients treated with adefovir (ADV) monotherapy or ADV in combination with lamivudine (3TC) after development of resistance to 3TC, with respect to biochemical improvement, HBV DNA suppression and development of subsequent ADV resistance. METHODS: All hepatitis B patients with 3TC resistance treated with ADV for 3 months or more at our centre were included, and monitored 3-6 monthly for biochemical and virological response, and development of ADV resistance. RESULTS: A total of 56 patients were included, 50% switched to ADV monotherapy and 50% received combination 3TC/ADV therapy. Median follow-up was 15.5 months. Normalization of alanine aminotransferase (ALT) occurred in 25 (89%) patients in the ADV group compared with 24 (86%) in the 3TC/ADV group (P = 0.686). Virological response (VR) was achieved in seven (35%) patients in the ADV group at 12 months compared with five (28%) in the 3TC/ADV group (P = 0.637). By 24 months, seven (64%) patients in the ADV group achieved VR compared with two (40%) in the 3TC/ADV group (P = 0.377). Cumulative probability of developing genotypic ADV resistance in the ADV group at 24 months was 18% compared with 7% in the 3TC/ADV group (P = 0.94). CONCLUSION: There was no obvious improvement in ALT normalization and virological suppression or reduction in the development of ADV-resistant mutations with 3TC/ADV therapy compared with ADV monotherapy. Further studies with longer follow-ups are required to determine whether combination 3TC/ADV therapy will reduce the emergence of ADV resistance compared with ADV monotherapy. |
| | |
Authors:
|
James Fung; Ching-Lung Lai; John Chi-hang Yuen; Danny Ka-Ho Wong; Yasuhito Tanaka; Masashi Mizokami; Man-Fung Yuen |
Related Documents
:
|
2032716 - Systemic interferon alpha-2b increases the cure rate in laser treated patients with mul... 7843696 - Ability of prolonged interferon treatment to suppress relapse after cessation of therap... 19586556 - Efficacy of consensus interferon in treatment of hbeag-positive chronic hepatitis b: a ... 20050936 - Is long-term virological response related to ccr5 delta32 deletion in hiv-1-infected pa... 11137806 - Preoperative lipid control with simvastatin reduces the risk for graft failure already ... 7590486 - Percutaneous gastrostomy for decompression in patients with advanced gynecologic malign... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Antiviral therapy Volume: 12 ISSN: 1359-6535 ISO Abbreviation: Antivir. Ther. (Lond.) Publication Date: 2007 |
Date Detail:
|
Created Date: 2007-05-16 Completed Date: 2007-06-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9815705 Medline TA: Antivir Ther Country: England |
Other Details:
|
Languages: eng Pagination: 41-6 Citation Subset: IM |
Affiliation:
|
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenine
/
analogs & derivatives*,
therapeutic use Adult Aged Alanine Transaminase / blood Asian Continental Ancestry Group* DNA, Viral / blood* Drug Resistance, Multiple, Viral* / genetics Drug Therapy, Combination Female Follow-Up Studies Genotype Hepatitis B virus / genetics* Hepatitis B, Chronic / blood, drug therapy*, genetics Hong Kong Humans Lamivudine / therapeutic use* Male Middle Aged Phosphonic Acids / therapeutic use* Reverse Transcriptase Inhibitors / therapeutic use* Time Factors Treatment Outcome Viral Load |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Viral; 0/Phosphonic Acids; 0/Reverse Transcriptase Inhibitors; 134678-17-4/Lamivudine; 142340-99-6/adefovir dipivoxil; 73-24-5/Adenine; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Renal function in antiretroviral-experienced patients treated with tenofovir disoproxil fumarate ass...
Next Document: A virological benefit from an induction/maintenance strategy: the Forte trial.