Document Detail

Addressing poor retention of infants exposed to HIV: a quality improvement study in rural Mozambique.
MedLine Citation:
PMID:  22622077     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Early infant diagnosis (EID) is the first step in HIV care, yet 75% of HIV-exposed infants born at 2 hospitals in Mozambique failed to access EID.
DESIGN: Before/after study.
SETTING: Two district hospitals in rural Mozambique.
PARTICIPANTS: HIV-infected mother/HIV-exposed infant pairs (n = 791).
INTERVENTION: We planned 2 phases of improvement using quality improvement methods. In phase 1, we enhanced referral by offering direct accompaniment of new mothers to the EID suite, increasing privacy, and opening a medical record for infants before postpartum discharge. In phase 2, we added enhanced referral activity as an item on the maternity register to standardize the process of referral.
MAIN OUTCOME MEASURE: The proportion of HIV-infected mothers who accessed EID for their infant <90 days of life.
RESULTS: We tracked mother/infant pairs from June 2009 to March 2011 (phase 0: n = 144; phase 1: n = 479; phase 2: n = 168), compared study measures for mother/infant pairs across intervention phases with χ², estimated time-to-EID by Kaplan-Meier, and determined the likelihood of EID by Cox regression after adjusting for likely barriers to follow-up. At baseline (phase 0), 25.7% of infants accessed EID <90 days. EID improved to 32.2% after phase 1, but only 17.3% had received enhanced referral. After phase 2, 61.9% received enhanced referral and 39.9% accessed EID, a significant 3-phase improvement (P = 0.007). In adjusted analysis, the likelihood of EID at any time was higher in the phase 2 group versus phase 0 (adjusted hazard ratio: 1.68, 95% confidence interval: 1.19 to 2.37, P = 0.003).
CONCLUSIONS: Retention improved by 55% with a simple referral enhancement. Quality improvement efforts could help improve care in Mozambique and other low-resource countries [added].
Philip J Ciampa; José A Tique; Nilton Jumá; Mohsin Sidat; Troy D Moon; Russell L Rothman; Sten H Vermund
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  60     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-24     Completed Date:  2012-07-25     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e46-52     Citation Subset:  IM; X    
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MeSH Terms
HIV Infections / drug therapy*
Health Services Administration*
Infant, Newborn
Medication Adherence*
Patient Acceptance of Health Care / statistics & numerical data*
Quality Improvement
Rural Population
Grant Support
D43 TW001035/TW/FIC NIH HHS; D43TW001035/TW/FIC NIH HHS; U2GPS000631//PEPFAR
Erratum In:
J Acquir Immune Defic Syndr. 2012 Jul 1;60(3):e106

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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