| Additive prognostic value of interleukin-6 at peak phase of dobutamine stress echocardiography in patients with coronary artery disease. A 6-year follow-up study. | |
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MedLine Citation:
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PMID: 18657656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Interleukin-6 (IL-6) and tissue factor (TF) are elevated after myocardial ischemia during dobutamine stress echo (DSE). We examined the incremental prognostic value of IL-6 or TF measured during DSE over echocardiographic and clinical factors in patients with chronic coronary artery disease (CAD). METHODS: We studied 106 patients with angiographically documented CAD. IL-6 and TF were measured at rest, peak, and during recovery. A wall motion score index was calculated. RESULTS: Fifty-seven (54%) patients had ischemia at DSE. During follow-up (63.7 +/- 20 months), 36 patients (33%) had an adverse event (12 cardiac deaths, 24 acute coronary events). Patients with events had a higher peak IL-6 (P = .02) but similar rest and recovery IL-6 than those without. Patients with peak IL-6 > or =3.14 pg/mL (upper tertile) had a hazard ratio of 2.7 (95% CI 1.44-5.37) (P < .01 for an adverse event). The addition of peak wall motion score index in a multivariable model including risk factors, ejection fraction, revascularization, and multivessel disease increased the model's c statistic from 0.66 to 0.70 (P = .04). The addition of peak IL-6 further increased the model's c statistic to 0.75 (P = .04). Tissue factor was not related with cardiac events. CONCLUSIONS: Interleuikin-6 levels measured during the peak phase of DSE incrementally contribute to risk stratification in patients with chronic CAD. |
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Authors:
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Ignatios Ikonomidis; George Athanassopoulos; Kimon Stamatelopoulos; John Lekakis; Ioanna Revela; Kiriaki Venetsanou; Margarita Marinou; Claudia Monaco; Dennis V Cokkinos; Petros Nihoyannopoulos |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: American heart journal Volume: 156 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-28 Completed Date: 2008-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 269-76 Citation Subset: AIM; IM |
Affiliation:
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2nd Cardiology Department, Attikon Hospital, University of Athens, Athens, Greece. ignoik@otenet.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Artery Disease / blood, diagnosis*, ultrasonography Echocardiography, Stress* Female Follow-Up Studies Heart Catheterization Humans Interleukin-6 / blood* Kaplan-Meiers Estimate Male Middle Aged Multivariate Analysis Prognosis Proportional Hazards Models ROC Curve Thromboplastin / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 9035-58-9/Thromboplastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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