Document Detail

Additive prognostic value of interleukin-6 at peak phase of dobutamine stress echocardiography in patients with coronary artery disease. A 6-year follow-up study.
MedLine Citation:
PMID:  18657656     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Interleukin-6 (IL-6) and tissue factor (TF) are elevated after myocardial ischemia during dobutamine stress echo (DSE). We examined the incremental prognostic value of IL-6 or TF measured during DSE over echocardiographic and clinical factors in patients with chronic coronary artery disease (CAD). METHODS: We studied 106 patients with angiographically documented CAD. IL-6 and TF were measured at rest, peak, and during recovery. A wall motion score index was calculated. RESULTS: Fifty-seven (54%) patients had ischemia at DSE. During follow-up (63.7 +/- 20 months), 36 patients (33%) had an adverse event (12 cardiac deaths, 24 acute coronary events). Patients with events had a higher peak IL-6 (P = .02) but similar rest and recovery IL-6 than those without. Patients with peak IL-6 > or =3.14 pg/mL (upper tertile) had a hazard ratio of 2.7 (95% CI 1.44-5.37) (P < .01 for an adverse event). The addition of peak wall motion score index in a multivariable model including risk factors, ejection fraction, revascularization, and multivessel disease increased the model's c statistic from 0.66 to 0.70 (P = .04). The addition of peak IL-6 further increased the model's c statistic to 0.75 (P = .04). Tissue factor was not related with cardiac events. CONCLUSIONS: Interleuikin-6 levels measured during the peak phase of DSE incrementally contribute to risk stratification in patients with chronic CAD.
Ignatios Ikonomidis; George Athanassopoulos; Kimon Stamatelopoulos; John Lekakis; Ioanna Revela; Kiriaki Venetsanou; Margarita Marinou; Claudia Monaco; Dennis V Cokkinos; Petros Nihoyannopoulos
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  156     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  269-76     Citation Subset:  AIM; IM    
2nd Cardiology Department, Attikon Hospital, University of Athens, Athens, Greece.
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MeSH Terms
Coronary Artery Disease / blood,  diagnosis*,  ultrasonography
Echocardiography, Stress*
Follow-Up Studies
Heart Catheterization
Interleukin-6 / blood*
Kaplan-Meiers Estimate
Middle Aged
Multivariate Analysis
Proportional Hazards Models
ROC Curve
Thromboplastin / analysis*
Reg. No./Substance:
0/Interleukin-6; 9035-58-9/Thromboplastin

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